Senior Scientist I, Cancer Immunology

About the role

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: As a key player in our Cancer Immunology team, you will use your immuno-oncology expertise to help advance Revolution Medicines’ assets in preclinical and clinical development.

Responsibilities

• Design, develop, validate and execute in vitro, in vivo, and ex vivo studies to address key translational questions and support immuno-oncology biomarker plans.
• Identify, evaluate and implement emerging technologies to enhance translational biomarker discovery and mechanistic understanding.
• Drive reverse translation efforts by formulating and testing hypotheses derived from clinical finding as appropriate to inform clinical development plans.
• Stay abreast of advances in tumor immunology and immunotherapy, identifying novel combination strategies and contributing to preclinical evaluation.
• Analyze, interpret, and communicate complex data effectively across internal cross-functional teams and at external scientific meetings.
• Represent Revolution Medicines at scientific conferences and other external engagements.

Requirements

• Ph.D. in immunology, cancer biology, or a related discipline, with deep expertise in tumor immunology, immuno-oncology biomarkers, and/or immunotherapy.
• Proven track record of research excellence, evidenced by high-impact publications.
• Expertise in in vivo model design to evaluate the efficacy and mechanisms of action of therapeutic agents and enable biomarker discovery, both internally and via contract research organizations.
• Strong technical expertise in immunology techniques including multi-parameter flow cytometric analyses, primary human cellular/tissue-based functional assays, cell biology and molecular biology to guide/inform mechanism of action and biomarker discovery.
• Strong problem-solving skills and ability to independently oversee scientific projects, rigorously analyze and interpret scientific data while maintaining attention to detail.
• Excellent written and verbal communication skills.
• Thrives in a fast-paced, collaborative, interdisciplinary team setting.
• 4+ years of relevant biotech or pharmaceutical industry experience in oncology drug discovery and development.

Skills

• Hands-on experience with humanized mouse models is desirable.
• Familiarity with multiomics analyses and integrating computational insights into experimental designs.

Pay

Base Pay Salary Range: $149,000 - $186,000 USD