Scientist/Senior Scientist, Immunology

About the role

NewLimit is a biotechnology company focused on extending human healthspan through the development of medicines that address age-related diseases by reprogramming the epigenome. Our approach involves functional genomics, pooled perturbation screening, and machine learning models to understand and intervene in the biology of epigenetic aging and disease.

Position

NewLimit seeks a Scientist/Senior Scientist in Immunology to lead and execute key discovery-to-preclinical research efforts in inflammatory and autoimmune diseases, with a strong focus on T cell and regulatory T cell (Treg) biology. The role involves designing and implementing in vitro screening assays to support lead selection and contributing to preclinical efficacy, safety, and mechanism-of-action studies. Collaboration with cross-functional teams is essential for advancing programs toward IND-enabling studies.

What you'll do

• Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and evaluate epigenetic reprogramming interventions for aged T cells, integrating and interpreting complex, multi-modal datasets
• Develop scalable functional assays in T cells and Tregs to predict therapeutic activity and inform lead selection
• Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development
• Contribute deep expertise in inflammatory and autoimmune disease biology to experimental design and data-driven program strategy
• Drive research in Treg biology, including differentiation, stability, and suppressive function
• Author or contribute to study reports, internal data packages, and regulatory-supporting documentation
• Mentor junior scientists and foster a collaborative, rigorous scientific culture
• Present data, analyses, and scientific recommendations clearly to internal teams and leadership

Requirements

• Ph.D. in immunology, cell biology, or a related field with 2+ years of industry experience, or BS/MS with 8+ years of relevant industry experience
• Hands-on experience with multi-parameter flow cytometry
• Experience designing in vivo models of autoimmune or inflammatory disease
• Experience with primary immune cell isolation, ex vivo culture, and Treg functional assay
• Experience authoring IND-supporting study reports

Nice to have

• Experience with pooled in vitro or in vivo screening approaches using bulk or single-cell readouts (e.g., CRISPR fitness screens, Perturb-seq, CROP-seq)
• Experience with rheumatoid arthritis and/or colitis models
• Experience managing or partnering with CROs to support preclinical studies, including alignment on study design, timelines, and data quality
• Familiarity with basic computational tools for data analysis (e.g., Python, R)

Benefits

NewLimit offers a comprehensive benefits package to support its team members:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site

The salary range for this position is $130,000 to $180,000, with compensation depending on various factors including qualifications, skills, competencies, and experience. NewLimit also offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: www.newlimit.com/careers.