Senior Scientist - Hematology & Medical Oncology

About the role

The Senior Scientist provides scientific and technical leadership in the management, design and execution of a clinical research program. With a broad range of skills and experience, this individual is a critical component of the Principle Investigators laboratory, demonstrating a capacity for collaboration and innovation with consistently high productivity. Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplant (HCT) and prevents this curative therapy from wider application in cancer patients. Gastrointestinal (GI) GVHD is the target organ that is most resistant to steroid treatment and acute GVHD in the GI tract accounts for the vast majority non-relapse mortality. This research project seeks to elucidate its basic biology and develop new laboratory strategies to predict its long-term outcomes. It explores the regeneration of crypts by Intestinal Stem Cells (ISCs) during GVHD, using in vitro model pathways that control inflammatory cell death.

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