Senior Scientist - Functional Genomics, High-Throughput Screening

About the role

Join Amgen’s mission of serving patients. This role is vital for discovery at Amgen, focusing on translating data into discovery, accelerating target discovery and prosecution.

Responsibilities

• Collaborate with Amgen therapeutic area scientists to leverage appropriate cellular models, gene delivery methods, and perturbation techniques to capture disease-relevant biology.
• Design, optimize, and execute functional arrayed genomic screens in advanced in vitro models (e.g. iPSC-derived cell types, co-cultures, primary cells, organoids, etc.).
• Partner with TD&B and cross-functional team members, including automation colleagues, to accelerate model deployment and reproducibility.
• Identify and implement emerging technologies in high content imaging, cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.

Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of functional genomic screening experience OR Bachelor’s degree and 5 years of functional genomic screening experience.
• Functional genomic screening experience; arrayed CRISPR (KO/i/a) and perturbation screening experience preferred; experience in high-throughput or automated screening preferred.
• Strong track record in cell engineering and complex in vitro model development.
• Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation.
• Experience with high-content imaging, automated microscopy, image analysis, feature reduction, and multivariate analysis preferred.
• Familiarity with high-throughput screening metrics (e.g. Z’, S/B, MSMR).
• Cell culture experience; iPSC experience and work in complex in vitro cellular models preferred.
• Experience with bioinformatics and computational analyses to harness meaningful results from genome-wide datasets.
• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models.
• Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights.
• Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment.

Skills

• Collaborative, innovative, and science based culture.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.