Senior Scientist, Epithelial and Stromal Biology - San Carlos, California

Candidates must be able to work onsite in San Carlos, California. At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic Alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision.
• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

About the role

As a Senior Scientist at BeOne Institute, you will independently design and execute high-quality research studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will contribute to target evaluation, mechanistic understanding, and therapeutic development through generation of rigorous, decision-enabling data.

Responsibilities

• Identify and advance high-value therapeutic targets across immunology, inflammation, and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities, and emerging scientific opportunities.
• Independently design, execute, analyze, and interpret in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.
• Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.
• May mentor junior scientists, research associates, and interns.

Requirements

• Ph.D., M.D., or equivalent advanced degree in one or more of the following areas: cancer biology, immuno-oncology, immunology, epithelial and stromal biology, stem cell biology, or a related life sciences discipline.
• 2+ years of related experience.
• Demonstrated track record of scientific achievements, as evidenced by publications in high-impact journals.
• Demonstrated ability to design experiments, generate high-quality data, analyze complex datasets, and communicate scientific findings effectively.
• Hands-on experience with relevant laboratory techniques such as primary human/mouse epithelial and stromal cell culture, air-lift culture, epithelial organoid culture, cell line engineering, histology, IHC, IF, flow cytometry, ELISA, MSD, molecular biology methods, protein characterization, microscopy/high-content imaging, or related experimental platforms.
• Experience with one or more of the following is preferred: in vitro and in vivo disease models, AI-driven protein design, protein engineering, induced proximity technologies, synthetic biology approaches, or other innovative therapeutic platforms.
• Knowledge of biologics, small molecules, and other complex modalities, experience with omics data analysis, and/or preclinical immunology and oncology mouse models is a plus.
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems.
• Strong collaboration skills across functional and disciplinary boundaries.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.

Skills

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Pay

Salary range: $150,200.00 - $187,800.00 annually. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location.

Benefits

• Annual bonus plan (non-commercial roles) or incentive compensation plan (commercial roles).
• Discretionary equity awards and voluntary participation in the Employee Stock Purchase Plan.
• Comprehensive benefits package including Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.