Senior Scientist, Immunology and Immuno-oncology - San Carlos, California)

About the role

BeOne Institute extends BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic Alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision.
• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will independently design and execute high-quality research studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will contribute to target evaluation, mechanistic understanding, and therapeutic development through generation of rigorous, decision-enabling data.

Candidates must be able to work onsite in San Carlos, California.

Responsibilities

• Identify and advance high-value therapeutic targets across immunology, inflammation, and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities, and emerging scientific opportunities.
• Independently design, execute, analyze, and interpret in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.
• Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.

May mentor junior scientists, research associates, and interns.

Requirements

• Ph.D., M.D., or equivalent advanced degree in one or more of the following areas: cancer biology, immuno-oncology, immunology, or a related life sciences discipline.
• 3+ years post-degree professional experience in academia and/or industry, with a demonstrated track record of scientific innovation and contributions to drug discovery or impactful scientific achievements.
• Demonstrated ability to independently design experiments, generate high-quality data, analyze complex datasets, and communicate scientific findings effectively.
• Experience with one or more of the following is preferred: immune organoid culture, AI-driven protein design, protein engineering, induced proximity technologies, synthetic biology approaches, or other innovative therapeutic platforms.
• Knowledge of biologics, small molecules, and other complex modalities, experience with omics data analysis, and/or preclinical immunology and oncology mouse models is a plus.
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems.
• Strong collaboration skills across functional and disciplinary boundaries.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.

Skills

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Pay

Salary range: $150,200.00 - $187,800.00 annually. Actual compensation packages are determined by several factors unique to each candidate, including job-related skills, depth of experience, certifications, relevant education or training, and specific work location.

Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All employees are eligible for discretionary equity awards and may voluntarily participate in the Employee Stock Purchase Plan.

Benefits

• Medical, Dental, and Vision coverage
• 401(k) retirement plan
• FSA/HSA
• Life Insurance
• Paid Time Off
• Wellness programs