Senior Scientist, Computational Protein Engineering

This position is responsible for planning and developing an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company. The role may involve supervising the work of others directly and/or across interdisciplinary teams.

Responsibilities

• Independently design and develop an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company.
• Develop computational pipelines for protein structure determination using structural and/or sequence-based methods and/or artificial intelligence methods (e.g., Rosetta, AlphaFold).
• Develop computational pipelines for protein docking and antibody epitope mapping.
• Independently combine data from different sources and analyze or incorporate these into multidimensional optimization of protein interactions.
• Lead a technical team to implement computational pipelines in protein design, engineering, or prediction.
• Critically evaluate experimental data and incorporate this knowledge into design.
• Provide input to the management team to identify, develop, and execute departmental initiatives and strategies.
• Lead technical team(s) to accomplish project goals and manage/coordinate work of other team members.
• Present findings/analyses and any associated issues/solutions to peer groups and managers; make recommendations for project advancement.
• Lead cross-functional initiatives with other business units on projects/products or associated deliverables.
• Establish and monitor direct report performance and development goals, assign accountabilities, set objectives, establish priorities, and provide continuous coaching and recognition on performance.
• Stay current with technological developments in area of expertise; expand knowledge through independent learning.
• Maintain organized, detailed, and clear project records for self and direct reports.
• Understand, follow, and enforce laboratory safety precautions to ensure compliance with company safety policies.

Requirements

• PhD in structural bioinformatics, molecular biology, bioengineering, biophysics, computational biology, or related field with 2 years of relevant experience.
• Expertise with protein and antibody modeling, including antigen-antibody interactions.
• Publications in the form of high-profile papers/patents within protein prediction or de novo protein design, including antibody or enzyme engineering.
• Experience with artificial intelligence and/or machine learning methods is desirable.

Skills

• Proven record of remaining current and learning new techniques/research in areas of computational biochemistry.
• Superior scientific fundamentals and analytical background.
• Ability to work independently and in teams, and to collaborate with external parties.
• Excellent communication skills and the ability to work in a highly dynamic and collaborative environment.
• Expert problem-solving skills and demonstrated ability to organize and move project tasks forward in an orderly and structured fashion.
• Strong analytical skills with the demonstrated ability to gather and evaluate complex data and information and develop recommendations and plans of action.
• Excellent organizational, planning, and time management skills; ability to manage multiple and often changing priorities and issues of varying complexity while meeting time-sensitive deadlines and deliverables.
• Strong leadership skills with demonstrated knowledge and understanding of staff management practices and processes; ability to establish accountabilities and expectations and manage performance to achieve results.
• Demonstrated propensity to be creative, collaborative, proactive, and self-motivated in the execution and completion of assigned tasks.
• Exceptional communication (written and verbal) skills regardless of the format (e.g., documents, public speaking situations, presentations, etc.).
• Project-level understanding and attention to detail with demonstrated commitment to excellence and performance.
• Proven proficiency with Microsoft Office (i.e., Word, Excel, PowerPoint, Outlook).

Physical Demands

• Frequently required to sit and stand for long periods.
• Occasionally required to walk; use hands and fingers to operate, handle, or feel objects, tools, or controls; reach with hands and arms.
• Up to 10% of the day may be spent at a laboratory bench.
• May work at heights above four (4) feet on occasion and move/lift up to 25 pounds.

Work Environment

• Laboratory environment working with chemical reagents and performing some Biosafety Level 2 work.
• May involve handling of BSL-2 materials and organisms including human blood and/or blood products.

Pay

The annual base salary for this position ranges from $116,600 to $177,800. This range represents a general guideline, as other factors are considered when presenting an offer of employment, such as scope and responsibilities of the position, external market factors, and the candidate’s knowledge, skills, abilities, education, and experience. Employees may qualify for a discretionary or non-discretionary bonus in addition to their base salary.

Benefits

• Comprehensive medical, dental, and vision coverage, along with prescription benefits.
• 401(k) plan with company matching.
• Flexible spending accounts.
• Company-paid short- and long-term disability insurance, group life, and accidental death and dismemberment insurance.
• Paid vacation, sick leave, holidays, and parental leave.
• Employee assistance program.
• Fitness club membership contribution.
• Pet insurance, identity theft protection, home and auto insurance discounts.
• Optional supplemental life insurance.