Senior Scientist, Biologics Purification II

About the role

Join AbbVie's Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity bispecific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).

Key Responsibilities

• Lead small-scale (
• Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production impurities and liabilities to deliver high quality biologics to therapeutic areas
• Apply Design of Experiments (DOE) with high throughput automation to optimize chromatography conditions for enhanced separation and resolution of complex protein mixtures
• Leverage AI and programming expertise to design and build data capture workflows and data warehousing infrastructure that supports machine learning development.
• Collaborate with multidisciplinary teams, translating molecular insights into functional results
• Stay current with emerging scientific literature to foster innovation and continuous improvement
• Present findings clearly to diverse audiences and document results with rigor

Requirements

• BS, MS, or PhD in Bioinformatics, Biophysics, Chemical Engineering, or related field with typically 12+ years (BS), 10+ years (MS), or 4+ years (PhD) of experience
• Deep proficiency in bioprocessing, column chromatography, and biotherapeutics manufacturing
• Experience operating high throughput automated liquid handling systems for chromatography applications (i.e. plate-based screening, robocolumns)
• Demonstrated success designing and executing DOE studies with successful application to protein production scale-up
• Experience with chromatography instrumentation and software (i.e. Unicorn) is required
• Experience developing bioinformatics tools and API’s for real-time data acquisition, extraction, and storage in LIMS environments is preferred.
• Familiarity with programming languages (i.e. Python) and AI/ML tools is a plus
• Strong understanding of molecular and post-translational attributes of biologics
• Exceptional analytical, communication, and presentation skills
• Collaborative spirit and dedication to scientific excellence

Qualifications

• BS, MS, or PhD in Bioinformatics, Biophysics, Chemical Engineering, or related field with typically 12+ years (BS), 10+ years (MS), or 4+ years (PhD) of experience
• Deep proficiency in bioprocessing, column chromatography, and biotherapeutics manufacturing
• Experience operating high throughput automated liquid handling systems for chromatography applications (i.e. plate-based screening, robocolumns)
• Demonstrated success designing and executing DOE studies with successful application to protein production scale-up
• Experience with chromatography instrumentation and software (i.e. Unicorn) is required
• Experience developing bioinformatics tools and API’s for real-time data acquisition, extraction, and storage in LIMS environments is preferred.
• Familiarity with programming languages (i.e. Python) and AI/ML tools is a plus
• Strong understanding of molecular and post-translational attributes of biologics
• Exceptional analytical, communication, and presentation skills
• Collaborative spirit and dedication to scientific excellence

Skills

• Programming languages (i.e. Python)
• AI/ML tools
• Design of Experiments (DOE)
• Data capture workflows and data warehousing infrastructure
• Collaboration with multidisciplinary teams
• Scientific writing and presentation

Benefits

• Comprehensive benefits package including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k)
• Participation in long-term incentive programs

Pay

$109,500 - $208,500 USD