Senior Scientist - AAV (CDMS) - Analytical and Biological Mass Spectrometry (ABMS)

About the role

The Analytical and Biological Mass Spectrometry Group (ABMS) at Regeneron Pharmaceutical's Tarrytown, NY site is seeking a highly motivated Senior Scientist to join their team. This role involves working in an innovative mass spectrometry lab to develop Liquid Chromatography-Mass Spectrometry (LC-MS) methods for characterizing biotherapeutic products across various stages of drug development.

Responsibilities

• Design, execute, and clearly communicate analytical characterization for biotherapeutics, including adeno-associated virus (AAV), monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities.
• Lead and execute characterization activities to evaluate and elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with a focus on charge detection mass spectrometry (CDMS) and related native-MS approaches.
• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
• Proactively advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
• Independently conduct sample preparation and LC-MS analyses in compliance with Standard Operating Procedures (SOPs), and document experimental procedures and results in an electronic laboratory notebook (ELN).
• Author and review regulatory submission documents, including Investigational New Drug (IND), comparability, and Biologics License Application (BLA) reports, and contribute to manuscripts for peer-reviewed publications.
• Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings.

Requirements

• A Bachelor’s (10+ years), Master’s (7+ years) or Doctorate (0-3+ years) degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
• Experience with charge detection mass spectrometry (CDMS) is strongly preferred.
• Experience applying LC-MS to extended characterization of AAV and monoclonal antibodies to support product and process development is a plus.
• Extensive experience with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec etc.).
• Experience with experimental design and data analysis (e.g., molecular modeling, graphing, and statistical analysis) is a plus.

Qualifications

• Thrives in a fast-paced, collaborative environment and consistently delivers results with efficiency and ownership.
• Quickly learns new technologies, tackles complex problems, and has a passion for science.
• Self-motivated and proactive, prioritizing effectively, and driving work forward with minimal supervision.

Skills

• Advanced knowledge of mass spectrometry techniques, particularly CDMS and native-MS approaches.
• Experience with LC-MS and data processing software.
• Strong communication and presentation skills.
• Ability to work independently and as part of a team.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on the country of employment: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit here. For other locations, additional information will be provided during the recruitment process.