Senior Scientist - AAV (CDMS) - Analytical and Biological Mass Spectrometry (ABMS)

About the role

The Analytical and Biological Mass Spectrometry (ABMS) group at Regeneron Pharmaceuticals, Inc. in Tarrytown, NY, is seeking a Senior Scientist to join their team. This role involves designing, executing, and communicating analytical characterization methods for biotherapeutic products, particularly adeno-associated virus (AAV), monoclonal and bispecific antibodies, and other modalities. The ideal candidate will lead and execute characterization activities to evaluate and elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with a focus on charge detection mass spectrometry (CDMS).

Responsibilities

• Design, execute, and clearly communicate analytical characterization for biotherapeutics, including AAV, monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities, to support drug development.
• Lead and execute characterization activities to evaluate and elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications, with an emphasis on CDMS and related native-MS approaches.
• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
• Proactively advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).
• Author and review regulatory submission documents, including IND, comparability, and BLA reports, and contribute to manuscripts for peer-reviewed publications.
• Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings.

Requirements

• A Bachelor’s, Master’s, or PhD degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
• Experience with charge detection mass spectrometry (CDMS) is strongly preferred.
• Experience applying LC-MS to extended characterization of AAV and monoclonal antibodies to support product and process development is a plus.
• Extensive experience with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec etc.).
• Experience with experimental design and data analysis (e.g., molecular modeling, graphing, and statistical analysis) is a plus.

Qualifications

• Self-motivated and proactive, prioritizing effectively, and driving work forward with minimal supervision.
• Quickly learn new technologies, tackle complex problems, and have a passion for science.
• Thrives in a fast-paced, collaborative environment and consistently delivers results with efficiency and ownership.

Skills

• Advanced knowledge of mass spectrometry techniques, including LC-MS and CDMS.
• Experience with sample preparation and LC-MS analysis.
• Strong communication and collaboration skills.
• Ability to work independently and as part of a team.

Benefits

• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

$109,900.00 - $179,300.00 annually

Schedule

Full-time