Senior Research Associate / Scientist, Proteomics Sample Prep

About the role

We're seeking a hands-on, detail-oriented Senior Research Associate / Scientist I to join our proteomics team and help scale our sample processing capacity. Reporting to our principal proteomics scientist, you'll spend most of your time at the bench following established SOPs, preparing and running high volumes of tissue and cell samples, and maintaining our Orbitrap Astral mass spec. This is a full-time, exempt, in-person position located in Berkeley, CA.

This role offers hands-on training on the Orbitrap Astral Zoom + Vanquish Neo platform and growing ownership of the workflow as our automated systems come fully online.

Responsibilities

• Prepare tissue and cell samples for mass spectrometry–based proteomics, including precise tissue dissection and cell pellet processing.
• Execute established protein and peptide enrichment strategies, including cell-surface labeling and immunopeptidomics workflows.
• Follow validated protocols for protein extraction and purification across a range of sample types.
• Utilize automation to achieve sample throughput at 96x plate format scale.
• Learn and operate the Orbitrap Astral Zoom, including routine instrument calibration and troubleshooting.
• Maintain consistent, reliable instrument performance by closely following established SOPs.
• Work closely with proteomics and cross-functional teams to keep sample processing on schedule.
• Document methods and maintain SOPs to support consistent, reproducible results.
• Communicate proactively, surfacing issues early rather than letting them surface downstream.
• Occasional weekend availability required (~1-2 hours).

Requirements

• Degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field.
• BS/MS with 2+ years of experience (Senior Research Associate) or 4+ years of experience (Scientist I).
• Hands-on experience with LC–MS/MS–based proteomics.
• Experience processing precious, complex clinical samples including tissue dissection and cell pellet handling.
• Demonstrated experience in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred).
• Familiarity with data independent acquisition (DIA).
• Excellent problem-solving skills and attention to detail.
• Strong written and verbal communication skills, with the ability to collaborate effectively with diverse scientific and technical colleagues.
• Ability to thrive in a fast-paced environment with evolving priorities.

Preferred Qualifications

• Experience with Thermo Orbitrap mass specs and Vanquish Neo LCs.
• Experience with cell surface proteomics or chemical labeling approaches.
• Familiarity with immunopeptidomics workflows (MHC-I/MHC-II).
• Experience performing LC-MS/MS on low-input samples (single-cell, spatial proteomics, immunopeptidomics).
• Familiarity with high-throughput proteomics workflows, automation, and sample multiplexing.
• Understanding of protein chemistry, post-translational modifications, and quantitative proteomics.
• Basic knowledge of bioinformatics tools or scripting (e.g., R, Python).

About Glyphic

At Glyphic Biotechnologies, we are developing a massively parallel, single-molecule proteome sequencing platform to transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised over $80M from venture partners and non-dilutive grant funding.

Work Environment

• Collaborative culture where your ideas and expertise are valued.
• Opportunity to learn from a diverse team of world-class scientists and engineers.
• Hands-on training and operation of state-of-the-art proteomics instruments.

Pay

Estimated base salary range: $82,000–$129,150 for the SF Bay Area, California location. Individual compensation is based on experience, education, skillset, and geographic location.

Benefits

• Employee Stock Option Plan.
• 100% health plan coverage for employees and dependents (medical, dental, and vision).
• Employer retirement contributions to 401(k).
• Generous paid time off.
• Paid maternity and paternity leave.
• Health and wellbeing program.
• Office snacks and beverages.
• Regular team bonding activities.