Senior Scientist, Proteomics

About the role

Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. In this role, you will play a critical role in the development and application of cutting-edge chemoproteomics workflows to support drug discovery programs and platform innovation.

Responsibilities

• Operate, maintain, and troubleshoot state-of-the-art LC-MS instrumentation, including Orbitrap Tribrid platforms with FAIMS
• Develop, optimize, and execute targeted chemoproteomics workflows to support discovery programs
• Design and improve scalable sample preparation and experimental workflows for high-throughput proteomics applications
• Analyze and interpret large-scale proteomics datasets using quantitative and statistical approaches
• Collaborate closely with proteomics, biology, chemistry, and computational teams to design experiments, interpret results, and guide project strategy
• Develop and implement innovative chemical proteomics technologies and methodologies to enhance platform capabilities
• Communicate findings and technical advances clearly across cross-functional teams

Qualifications

• Ph.D. in analytical chemistry, chemical biology, biochemistry, or a related discipline with 4+ years of industry experience, or M.S. degree with 6+ years of industry experience
• Extensive hands-on experience with mass spectrometry-based proteomics workflows and instrumentation
• Experience with quantitative proteomics methods including TMT, DIA, PRM, or related approaches
• Experience with targeted chemoproteomics workflows and applications
• Experience with peptide mapping and/or intact mass spectrometry is preferred
• Proficiency in analyzing complex, large-scale proteomics datasets using computational methods and programming languages such as Python or R
• Expert level understanding of proteomics data analysis software (e.g. MSFragger, ProteomeDiscoverer, Spectronaut, MaxQuant)
• Strong understanding of experimental design, assay optimization, reproducibility, and quantitative data interpretation
• Experience with laboratory automation platforms (e.g., Hamilton, Agilent Bravo) is a plus
• Excellent communication and cross-functional collaboration skills
• Demonstrated ability to work independently and manage multiple priorities in a fast-paced environment

Location

Cambridge, MA

Benefits

Expedition Medicines offers healthcare coverage, an annual incentive program, retirement benefits, and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicines's good faith estimate as of the date of publication and may be modified in the future.