Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)
Research$84k–$114k/yrOther
We need to output HTML fragment with sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. Only include sections that have real specific content. We must not repeat job title heading. Must not include Job ID etc. Must remove boilerplate. Must preserve all substantive info.
We need to parse the posting.
Key sections:
- About Arc Institute: description of organization. Could be "About the role"? Actually "About the role" is a heading for description of position. The posting includes "About The Position". So we can put that under
About the role
with paragraphs.
- Responsibilities: list of duties: "In this position you will Execute culture, quality control and validation of complex in vitro 3D neural and glial models. Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc. Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models. Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility. Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system. Collaborate with other teams at Arc to coordinate screening steps and sample transfer. Analyze and present experimental data at internal meetings and seminars."
Also earlier bullet: "You will play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens." Could be part of responsibilities.
We can combine.
- Requirements: list: BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience; Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar), with reliable, reproducible results; Demonstrated ability to execute multiple cell culture protocols with precision and to transition between them accurately, maintaining fidelity to each protocol's specific requirements (workflow, media, and timeline); Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts; Excellent aseptic technique and consistent cell-culture practice held to a high, production-type standard; Meticulous documentation and record-keeping; comfort working to a production schedule, and basic data tracking and analysis; Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required.
- Preferred Qualifications: Hands-on experience handling high throughput plate formats and automation methods; Experience with LIMS systems, ideally Benchling; Experience analyzing large data sets preferably using data scripting tools such as Python or R.
- Skills: maybe we can extract from "About You": love science and learning; highly independent; plan and execute projects; work fast and detail-oriented; careful and diligent about documentation; use specialized skill sets; collaborate effectively across teams; mentor and train junior RAs; comfortable carrying out routine execution while identifying opportunities to troubleshoot and improve bottlenecks; organizational skills enable managing multiple concurrent projects; curiosity and creativity drive continuous learning. Could be considered Skills.
- Pay: The base salary range for this position is $84,250 to $114,250. Also note about compensation details. We can include Pay section with that range.
- Benefits: Not mentioned explicitly. There's mention of "substantial long-term philanthropic funding" but not benefits. No explicit benefits like health, retirement. So we should not create Benefits section unless posting actually states them. It does not. So omit.
- Schedule: "This is a temporary contractor position based onsite 5 days a week in Palo Alto." Also "Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required." So schedule: Onsite 5 days/week, occasional weekend work. Could be Schedule section.
We must not include filler like "commensurate with experience". Not present.
We must not include duplicated lines. Ensure we preserve all substantive info.
We need to output only HTML fragment, no markdown fences.
Structure:
About the role
... paragraphs ...
Responsibilities
Requirements
Preferred Qualifications
Skills
Pay
The base salary range for this position is $84,250 to $114,250. ... maybe include note about factors.
Schedule
This is a temporary contractor position based onsite 5 days a week in Palo Alto. Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required.
We must not repeat job title heading. Not include "About Arc Institute" as separate heading? Could be part of About the role? The instruction: "use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule)." So we should follow those headings. The "About Arc Institute" description could be placed under About the role as introductory paragraph. That's fine.
We must not include boilerplate like EEO etc. Not present.
Now craft content.
About the role paragraph: combine Arc Institute description and "Why this position could be the best job you’ve ever had" and "About The Position". Let's write a concise paragraph preserving all substantive info.
Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco. Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone. Our Two Institute Initiatives Reflect This Model In Action Virtual Cell Initiative: Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials. Alzheimer's Disease Initiative: Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes. More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding. Why this position could be the best job you’ve ever had Join Arc's Alzheimer's Disease Initiative as the production engine behind a first-of-its-kind 3D brain-model screening program, where the cells you make drive disease-target discovery. About The Position We are seeking a Senior Research Associate, In Vitro Screen Execution, to join the Cellular Models Technology Center for a fixed term of 12 months to support the execution of arrayed genetic and chemical perturbation screens in disease-relevant 3D neural models. In this position, you will play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens. Through this work, you will play a critical role in the Institute's Alzheimer's Disease Initiative, an ambitious cross-functional effort aimed at identifying and developing drugs for rational therapeutic targets to combat devastating neurodegenerative disorders. This is a temporary contractor position based onsite 5 days a week in Palo Alto. This role is not eligible for visa sponsorship.
We can keep that as About the role.
Now Responsibilities list items:
- Execute culture, quality control, and validation of complex in vitro 3D neural and glial models.
- Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.
- Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models.
- Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.
- Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.
- Collaborate with other teams at Arc to coordinate screening steps and sample transfer.
- Analyze and present experimental data at internal meetings and seminars.
- Play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens. (maybe duplicate; but we can keep unique.)
We might combine similar.
Now Requirements list:
- BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience.
- Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar), with reliable, reproducible results.
- Demonstrated ability to execute multiple cell culture protocols with precision and to transition between them accurately, maintaining fidelity to each protocol's specific requirements (workflow, media, and timeline).
- Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts.
- Excellent aseptic technique and consistent cell-culture practice held to a high, production-type standard.
- Meticulous documentation and record-keeping; comfort working to a production schedule, and basic data tracking and analysis.
- Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required.
Now Preferred Qualifications list:
- Hands-on experience handling high throughput plate formats and automation methods.
- Experience with LIMS systems, ideally Benchling.
- Experience analyzing large data sets preferably using data scripting tools such as Python or R.
Now Skills list (from About You):
- Love science and learning; continuously curious and enjoy stepping out of comfort zone to learn new things.
- Highly independent in developing and executing experiments and workflow designs aligned with team and project goals.
- Able to plan and execute projects and individual experiments with independence.
- Work fast and detail-oriented.
- Careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.
- Use specialized skill sets to support lab teams and cross-functional projects.
- Collaborate effectively across teams without detailed guidance by manager or mentor, including engaging with people with different work styles.
- Directly mentor and train more junior RAs inside or outside your lab or team.
- Comfortable carrying out routine execution of tasks while identifying opportunities to troubleshoot and improve bottlenecks.
- Organizational skills enable managing multiple concurrent projects.
- Curiosity and creativity drive continuous learning.
Now Pay paragraph: include base salary range and note about factors.
We have: "The base salary range for this position is $84,250 to $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits."
We can keep that.
Now Schedule paragraph: "This is a temporary contractor position based onsite 5 days a week in Palo Alto. Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required." Might be redundant but okay.
We must not include "This role is not eligible for visa sponsorship." That's substantive; maybe include in About the role or Schedule? It's about eligibility. Could be placed in About the role paragraph. We'll add a sentence: "This role is not eligible for visa sponsorship."
Now ensure no duplication