Senior Research Associate, DNA Encoded Library Technology ~ Contract

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. We aim to improve treatment options for patients with cancer and inflammatory diseases through a fully AI-integrated discovery engine and unparalleled ligase expertise.

About the role

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation.

Responsibilities

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
• Construct DEL libraries to support the in-house library production efforts.
• Work with external partners to support our DEL synthesis and hit follow-up strategies.
• Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning, and hit-optimization.
• Contribute to platform automation and technology development efforts.
• Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Requirements

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry.
• 2–5 years of industrial experience (title determined by experience).
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA-encoded libraries.
• Familiar with the overall DNA-Encoded Library Technology workflow operations.
• Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Qualifications

• Experience working in the drug discovery field – drug design, synthesis, and SAR-based hit-to-lead optimization.
• Experience working with high-throughput analytical and purification systems relevant to DEL applications.
• Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Skills

• Collaborative and team-oriented, eager to share expertise and learn from others.
• Solution-driven with a hands-on and resourceful approach.
• Adaptable and comfortable in a fast-paced, interdisciplinary environment.
• Committed to scientific excellence and the shared goals of the team.

Pay

$58/hr - $65/hr

Location: Brisbane, CA