Contract Senior Associate Scientist, Biochemistry

Location: On-site (Cambridge, MA)

About the role

Our Cambridge-based biotechnology client is seeking a hands-on scientist to support biochemical assay execution, compound screening, and recombinant protein production in a collaborative drug discovery environment. This role will partner closely with biology, chemistry, and protein sciences teams to generate high-quality data that supports therapeutic discovery programs.

Responsibilities

• Execute biochemical and biophysical assays, including FP, TR-FRET, AlphaLISA, SPR, DSF, and analytical SEC.
• Perform compound screening, data capture, QC analysis, and assay troubleshooting.
• Support assay development, optimization, reagent qualification, and workflow improvements.
• Express, purify, and characterize recombinant proteins using chromatography-based methods.
• Conduct protein QC using SDS-PAGE, analytical SEC, and related analytical techniques.
• Maintain laboratory reagents, equipment, inventory, and documentation.

Requirements

• BS with 6+ years or MS with 2+ years of industry experience in biochemistry, molecular biology, or a related field.
• Experience with biochemical and/or biophysical assays in a drug discovery setting.
• Hands-on experience with protein purification and characterization techniques.
• Familiarity with high-throughput screening workflows and automated liquid handling is a plus.
• Strong attention to detail, data quality, and scientific documentation.
• Excellent communication and collaboration skills.

Preferred Qualifications

• Experience with recombinant protein expression in bacterial, mammalian, or insect systems.
• Knowledge of chromatography-based purification methods and assay QC metrics.
• Experience supporting oncology, targeted protein modulation, peptide therapeutics, or related discovery programs.

Benefits

• Supplemental medical, dental, vision, life, and disability insurance plans.
• Employee Stock Purchase Program (ESPP).
• 401K program with company match after 12 months of tenure.
• Health Savings Account (HSA) on the HDHP plan.
• SupportLinc Employee Assistance Program (EAP) with up to 8 free counseling sessions.
• Corporate discount savings program and other discounts.
• On-demand training program and access to certification prep, technical/leadership courses, books, and seminars after 6+ months of tenure.
• Certification discounts and association perks (e.g., CompTIA, IIBA).
• Dedicated customer service team and certified Career Coach for consultants.