Senior Principal Scientist, Lab Head, Immunomodulation / Cell Reprogramming

About the role

Sanofi Oncology is seeking a highly motivated individual with project leadership experience and deep knowledge in immuno-oncology. This individual will play a leading role in developing novel cell reprogramming and other therapies aimed at modifying the tumor microenvironment to treat cancer. The successful candidate will lead a team within the Immunomodulation & Cell Reprogramming Cluster where they are expected to support Progression of existing programs, develop new projects, and contribute to the growth of the Immuno-Oncology portfolio. The position is based in Cambridge, Massachusetts, USA.

Main Responsibilities

• Lead and manage a team of scientists and cross-functional research teams, ensuring timely progression of projects from early concepts to first-in-human studies
• Mentor and develop team members, fostering scientific excellence, professional growth, and a lead-by-example culture
• Develop clear scientific strategies to support departmental goals and allocate resources to drive overall group performance
• Demonstrate innovation in research with deep understanding of clinical translation
• Apply scientific expertise to initiate, design, direct, and execute experiments while ensuring compliance with laboratory safety and documentation protocols
• Keep current with developments in basic research, clinical development, and the competitive landscape
• Publish and present findings in peer-reviewed journals and scientific conferences

About You

• Ph.D. in Immunology, Immuno-Oncology, Cell Biology, Molecular Biology, or related discipline
• Minimum of 7 years of post-graduate research experience in the pharmaceutical, biotechnology, or related industry
• Deep knowledge in immunological mechanisms or tumor immunology
• Experience in cell therapy and/or tumor microenvironment research
• Hands-on experience in isolation and immune phenotyping of murine and human immune populations (e.g., cell sorting, flow cytometry), functional assessment of immune subsets (e.g., proliferation, cytotoxicity, cytokine/chemokine measurement), and murine tumor models including immune deficient and humanized mice
• Familiarity with techniques for genetically modifying immune cells to express novel transgenes
• Excellent organizational, communication, and presentation skills with the ability to work both collaboratively and independently

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future-focused team
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science
• Help improve the lives of millions of people globally by making drug development quicker and more effective
• Achieve genuine work-life balance in a supportive R&D environment