Senior/Principal Scientist IHC

Responsibilities

• Design and optimize chromogenic IHC assays using FFPE/FF samples
• Confirm specificity using orthogonal methods (e.g., ISH)
• Lead histopathology support for cancer target programs, including materials management, hands-on lab work, mentorship of junior staff, and timeline delivery
• Present results, gather feedback, and implement next steps
• Use literature and public datasets to guide assay development and target validation
• Process tissues and cell pellets into FFPE/frozen blocks; section and stain samples using Leica Bond autostainers
• Digitize slides, analyze results, and document data in ELN and presentations
• Perform routine lab tasks: sample archiving, equipment maintenance, consumables ordering, logistics
• Support tissue database and digital data organization

Qualifications

• PhD +4 years, or Master’s +6 years, or Bachelor’s +8 years or more of hands-on experience working in histology and IHC related labs, preferably supporting cancer research in an industry setting
• Extensive (>3 years) hands-on experience developing, utilizing, and interpreting immunohistochemistry assays against novel protein targets, using both single and multiplex IHC techniques primarily on FFPE sample slides
• Extensive (>3 years) hands-on experience in laboratory histology, including preparation of tissue samples into FFPE and FF blocks, preparation of cell pellet control blocks, cryostat and microtome sectioning, troubleshooting chromogenic IHC and ISH experiments, and independently identifying appropriate next steps in the development of robust, sensitive and specific tissue biomarker assays
• Experience with Leica Bond autostainers and reagents relevant to optimizing new IHC assays, typically chromogenic assays
• Experience with microscope slide scanners for brightfield and fluorescent imaging, and general experience utilizing whole-slide image analysis software such as HALO
• Collaborate effectively in a matrix-managed organization to drive advancement of early-stage projects into translational and clinical development
• Be relied upon as a technical expert in the IHC field; provide guidance to colleagues and collaborators, and mentorship to more junior lab colleagues