Senior / Principal Scientist, Biochemistry

Responsibilities

• Propose, design, and implement biochemical assays for compounds testing and mechanism-of-action studies.
• Lead from the bench to propose and develop new assays and drive hit identification, hit-to-lead, and lead optimization experiments in collaboration with a cross-functional project team.
• Design and conduct high-quality scientific experiments.
• Apply biochemical methods to enable mechanistic studies and determine the mode of inhibition for promising hits.
• Analyze, interpret, and communicate high-quality data to a cross-functional project team.
• Collaborate with chemistry, biology, lead discovery, and medicinal design teams to characterize and establish SAR, rapidly advancing the hit-to-lead process.
• Propose and evaluate new approaches and technologies.
• Provide scientific leadership, mentorship, and cross-functional partnership within a dynamic matrixed environment.

Qualifications

• PhD in biochemistry or a related discipline with 5+ years of industry experience, or a comparable combination of postdoctoral training and industry experience.
• Strong knowledge and understanding of steady-state enzyme kinetics and binding assays.
• Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein–ligand binding interactions.
• Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaLISA, DSF.
• Experience with validating hits coming from DEL screening campaign.
• Strong attention to detail, with excellent troubleshooting and problem-solving skills.
• Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.

Preferred Qualifications

• Knowledge of automation and experience with assay validation for HTS is beneficial.
• Experience using numerical simulations for experiment set up and data analysis.
• Experience in working with challenging proteins.
• Working knowledge of adjacent disciplines (biophysics, structural biology, protein purification, biology, chemistry).
• General knowledge of signaling pathways, protein homeostasis, and regulation of gene expression beneficial.
• Track record of publications in high-impact scientific journals.