Senior Medical Director, Clinical Development

Key Responsibilities

• Serve as physician lead and medical monitor for REM-422 clinical studies, with direct accountability for patient safety, protocol adherence, and scientific and ethical rigor
• Review and assess Serious Adverse Events (SAEs), including narrative writing, causality assessment, and reconciliation with the safety database
• Respond to site medical queries, review eligibility exceptions, and support investigators on protocol requirements and deviation management
• Author and revise clinical documents including protocol synopses, Investigational Brochure (IB) sections, Informed Consent Forms (ICFs), and Case Report Form (CRF) narratives
• Interpret evolving clinical data — including safety trends, pharmacokinetic/pharmacodynamic (PK/PD) signals, and emerging biomarker findings — and bring forward clear recommendations to the Chief Medical Officer and senior clinical team

Qualifications

• MD or equivalent medical degree
• 5+ years of oncology clinical development experience within a biotech or pharmaceutical organization
• Hands-on experience as a medical monitor or clinical study physician, including SAE review and site oversight
• Familiarity with early-phase (Phase 1/1b) oncology trial design and execution
• Working knowledge of ICH/GCP guidelines and FDA regulatory requirements
• Strong scientific acumen with ability to engage deeply with translational data and biomarker-driven programs
• Excellent written and verbal communication; able to author clinical documents and synthesize complex data for varied audiences

Preferred

• Experience with rare solid tumors, adenoid cystic carcinoma (ACC), or head and neck oncology
• Exposure to hematologic malignancies (acute myeloid leukemia, myelodysplastic syndromes)
• Experience on biomarker-heavy or genomically-selected programs
• Familiarity with RNA or spliceosome biology

Pay

Salary Range: $230,000-$330,000 USD