Senior Director, Global Program Development Lead - DMD/Neuromuscular

About the role

Lead overall program strategy, accountable for an integrated Program Development Strategy, Target Product Profile (TPP), and lifecycle management plan aligned with corporate objectives and long-term portfolio goals to maximize asset value.

Responsibilities

• Leverage deep expertise in drug development and commercialization, along with a forward-looking perspective and strong operational mindset, to ensure the program team operates with clarity, rigor, and urgency while fostering collaboration and high performance.
• Guide the program’s path forward by anticipating opportunities, mitigating risks, cultivating strategic options, and driving decision-making amid complexity and uncertainty to achieve long-term program success.
• Lead cross-functional strategic integration, ensuring scientific rigor and emerging clinical data, competitive intelligence, and evolving market dynamics inform program direction and critical decisions.
• Identify key development challenges and define strategic options across functions, including timelines, budgets, risks, and trade-offs, enabling timely, high-quality decision-making.
• Support business development activities, including opportunity assessment and due diligence; represent the program on Joint Steering Committees for partnered assets.
• Maintain external perspective and scientific credibility through engagement with KOLs, patient advocacy groups, and other external experts.
• Evolving and maturing the program’s external communications strategy in partnership with key groups, including the elements of scientific messaging, competitive positioning, and stakeholder alignment.
• Drive cross-functional program execution within a matrix organization, ensuring high-quality, on-time deliverables while aligning priorities and resources to maximize program value and proactively resolve critical challenges.
• Anticipate operational and strategic risks, establish contingency plans, and pressure-test assumptions, timelines, and budgets to maintain program agility and informed decision-making.
• Serve as the primary liaison between the Core Team and governance committees, presenting program materials with clear, data-driven recommendations and actionable options to support timely approvals.
• Build, influence, and sustain high-performing teams, guiding complex, high-stakes decisions without direct authority.
• Lead cross-functional teams to deliver high-impact program outcomes, challenging assumptions, timelines, and budgets while developing alternative scenarios to mitigate risk and maximize value.
• Own the quality, integrity, and timeliness of team outputs, ensuring company-level decisions are informed by robust, high-caliber data; set pace and priorities to achieve milestones in a highly competitive landscape.
• Lead with pragmatism and clarity through ambiguity, charting the path forward and driving complex drug development decisions in fast-paced, dynamic environments.
• Travel up to 20%.

Requirements

• Bachelor’s degree required; advanced degree (MS, PhD, MBA) in life sciences or healthcare field preferred.
• Proven leader with 8+ years in pharmaceutical industry leadership, with a strong track record driving drug development programs through pivotal stages to commercialization; product launch and early commercialization experience is a strong plus.
• Strong understanding of drug development and commercialization processes, ideally within rare disease or gene therapy.
• Deep knowledge of neuromuscular diseases is highly desirable.
• The ability to work well under intense pressure, tight timelines, and in rapidly changing situations.
• Evidence of an entrepreneurial spirit and a capacity to find creative solutions to unexpected hurdles.
• Interacts effectively across teams with supporting REGENXBIO functions and disciplines using influencing, communication and relationship building skills.
• Commitment to anticipate, influence and direct change.
• Excellent listening and collaboration skills.

Qualifications

• Experience in leading drug development programs from preclinical to commercialization.
• Strong understanding of regulatory requirements and processes.
• Ability to manage multiple projects simultaneously and prioritize tasks effectively.
• Excellent communication and interpersonal skills.
• Proven ability to build and lead high-performing teams.
• Knowledge of neuromuscular diseases is highly desirable.

Skills

• Strategic planning and execution.
• Project management and organizational skills.
• Collaboration and teamwork.
• Leadership and mentoring.
• Communication and presentation skills.
• Regulatory compliance and understanding.

Benefits

• Comprehensive and competitive benefit & compensation package which includes market-competitive salaries, an annual bonus program, education assistance, retirement plan with employer match, stock options at all levels, summer hours and more!
• The estimated compensation range for this role is $235,000 to $335,000 annually.

Pay

The estimated compensation range for this role is $235,000 to $335,000 annually. The actual salary offered to the final candidate depends on a number of factors such as relevant work experience, skills, education, and years of experience.

Schedule

Full-time position.