Senior Director, Global Medical Affairs, GI Oncology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, currently in clinical development.

About the role

Reporting to the GI Tumors Medical Affairs Strategy Lead, the Senior Director, Global Medical Affairs, will develop and execute the Global Medical Affairs (GMA) strategy and tactical plans with a focus on launch readiness, launch implementation, and life cycle management for an individual asset. This role requires close collaboration with cross-functional counterparts across Development, Research, and Commercial, as well as other internal partners, to design and implement a comprehensive medical affairs strategy for assets in the GI space, with a focus on PDAC and CRC.

Responsibilities

• Develop and execute the GMA strategy and medical objectives, including activities related to scientific engagement and communication, evidence generation, internal education, and patient advocacy.
• Develop and execute a Health Care Professional (HCP) engagement strategy to gather insights to shape internal programs.
• Act as the medical representative on cross-functional teams and serve as a therapeutic area content expert.
• Participate in the Global Medical Affairs Team (GMAT) to execute medical strategies, contribute to the operations and oversight of medical activities, and support pre-launch activities.
• Support routine gap assessments leading to the development/refinement of publication strategy, evidence generation plans, and tactical plans as part of the overall GMA plan.
• Provide medical leadership in scientific engagement activities with key external stakeholders through advisory boards, investigator interactions, congress activities, and peer-to-peer discussions.
• Communicate clinical and scientific data to KOLs and other healthcare professionals through presentations, educational programs, and scientific discussions.
• Represent various medical affairs functions in cross-functional strategy team meetings, including Clinical and Safety sub-teams, Global Brand Team, Global Product Team, Patient Advocacy, Market Access, and other strategic discussions.
• Work closely with Clinical and MSL teams to provide enrollment, scientific, and engagement support to ensure clinical trials meet study timelines.
• Partner with RWE strategy and Biomarker/CDx teams on integrated evidence generation strategies and activities as part of the GMA Plan.
• Work with Patient Advocacy and Grants teams to incorporate the patient voice and define external medical education strategies for independent grants.
• Provide medical support for scientific symposia and medical congresses, and collaborate across GMA functions to develop, review, and align on key scientific communication points and medical information response documents within legal and compliance guidelines.
• Support the review and approval of abstracts, manuscripts, corporate communications, and other data disclosure documents, as well as internal stakeholder medical education activities related to compound data and competitor data.
• Collaborate with stakeholders across the organization, including Clinical Development and Operations, Commercial Operations, Program Management, Business Development, Regulatory, Safety, and Compliance teams.

Requirements

• An advanced doctorate degree (PharmD, PhD, MD, DO or equivalent) in a medical or scientific area is required.
• 15+ years of relevant experience in Medical Affairs within the biotech and/or pharmaceutical industry (local, regional, and global levels) and/or prior clinical oncology practice.
• Strong scientific background in oncology, with preferred experience in GI cancers, and ability to effectively analyze, synthesize, and communicate complex scientific information.
• Direct, hands-on experience executing activities across key medical affairs functions, including training, medical communications, medical information, expanded access programs, evidence generation tactics, and publications.
• Proven track record of clinical trial support, including protocol development and review, site selection and enrollment support, and data analysis.
• Excellent interpersonal, written, and presentation skills with the ability to effectively communicate complex scientific data to diverse audiences.
• Ability to thrive in a fast-paced, dynamic environment, managing multiple priorities independently with limited supervision.
• Ability to travel to Redwood City headquarters and professional conferences (30 - 40%).
• Strong networking skills with deep, existing relationships with GI cancer healthcare professionals, including global key opinion leaders.

Preferred Qualifications

• Experience in global product launches, including support of integrated brand plan ideation, regulatory submissions, reimbursement, and label development.
• Experience in guideline submissions (e.g., NCCN) and engagements with global health authorities.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $232,000 - $290,000 USD. The range is determined by role, level, and location, with individual base pay salary influenced by job-related skills, experience, market dynamics, and relevant education or training.