Senior Director, DMPK Project Leader

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026. Description Of Role Senior Director, DMPK Project Leader ensures delivery of all DMPK related activities working collaboratively as part of a cross-functional program team. These include nonclinical PK experiments, in vitro ADME, biotransformation studies, bioanalytical and toxicokinetic analysis. This role supports understanding pharmacokinetic, toxicokinetic, and ADME principles to enable progression of drug candidates across the portfolio. A qualified candidate will have previous experience in PK modeling ideally for CNS drug candidates and a basic understanding of vital ADME properties for CNS drug candidate progression. Furthermore, a qualified candidate will have end-to-end experience in drug discovery and development including NDA submission; will be able to partner with both discovery and development teams to enable the identification of lead candidates with optimal DMPK properties for progression into nonclinical development and the progression of lead candidates into clinical development. Key Responsibilities Lead the filing of NDAs for DMPKDeliver high-quality DMPK input and data to projects within established timelinesUtilize knowledge of DMPK to support/influence compound profiling, project progression and project strategyProactively calculate PK and toxicokinetic parameters, estimate safety margins and report results and interpretations to project teams and internal governance bodiesLead, coordinate, and engage with DMPK colleagues, clinical pharmacologists, and toxicologists in project related activitiesPrepare clear presentations related to the above for internal governance bodies Qualifications Ph.D. in Pharmaceutical Sciences, Pharmacology or a related fieldMinimum of 10 years of industry experience in a biotech or pharmaceutical settingExpert in DMPK sciences with knowledge of drug discovery and development processesStrong analytical and problem-solving skillsExperience in DMPK project leadershipPrevious work in the discovery and/or development of CNS drug candidatesExperience with regulatory submissions including NDAs for small moleculesKnowledge, experience, and proficiency in supporting GLP-compliant studiesGood knowledge of all DMPK assays including the use of in silico tools for PK predictionProficiency with Phoenix WinNonlin and other software for NCA and PK modeling in small molecule drug discovery and developmentDemonstrated ability to work cross-functionally and communicate scientific findings clearly and effectivelyCollaborative mindset and operates with a sense of urgencyStrong, proactive communication skills Work Location The Senior Director, DMPK Project Leader role based in the US, with occasional travel. Compensation The annual base salary range for this position is $200,000.00 to $215,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge an location. In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. POSITION: Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.