Senior Associate Scientist, R&D Chemistry

About the role

We are currently seeking a synthetic organic chemist for the R&D (Research & Development) Chemistry group. In this position, they will play an important role in supporting Regeneron small molecule antibody-conjugate drug discovery capabilities, providing an important link with the company's existing expertise in biologics and novel genetic medicines.

Responsibilities

• Support the discovery and generation of novel small-molecule payloads and linkers for antibody-drug conjugate therapeutics across various therapeutic areas including oncology, metabolic disease/obesity, infectious diseases, immunology and inflammation, neuroscience, and ophthalmology.
• Work independently while deploying modern organic synthesis strategies and techniques to biologically active targets of interest.
• Interpret spectroscopic data to confirm small molecule structures.
• Collaborate with cross-functional teams to identify new strategies and technologies best suited for synthetic execution of targets of interest.
• Participate in departmental and cross-functional meetings to contribute expertise and represent the goals of the R&D Chemistry group.
• Engage in discussions with biological data and new targets within existing projects to address structure-activity relationship directions.

Requirements

• Masters Degree in synthetic organic chemistry (or related field).
• Familiarity with drug discovery processes and modern methods of synthetic organic and medicinal chemistry.
• Minimum of 5-7 years of industry drug discovery experience with small molecules.
• A general understanding of biological target validation, ADME/PK, PD/efficacy, and the role of medicinal chemistry in these areas is a plus.
• Experience with peptidomimetics or antibody-targeted therapeutics is a plus.

Qualifications

• Passionate and enthusiastic about the promise of small molecule-based, antibody-targeted therapeutics and the challenges of synthetic chemistry and drug design.
• Comfortable working as part of a cross-functional team.

Skills

• Small-molecule synthetic organic background.
• Experience with retrosynthetic analysis and synthetic route design.
• Hands-on execution of multistep synthetic protocols including compound isolation and characterization.
• Understanding of modern organic synthesis strategies and techniques.
• Ability to work independently while deploying them in a fit-for-purpose efficient approach to biologically active targets of interest.
• Knowledge of the latest synthetic methods utilized in the antibody-conjugate linker generation.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Pay

$80,300.00 - $131,100.00 annually

Schedule

Full time