Senior Associate Scientist - Oncology Discovery

Position Responsibilities

• Designs and executes experiments based on cell and molecular biology protocols
• Analyzes and interprets experimental data
• Prepares and presents experimental results to project team leaders
• Works within established procedures to perform large-scale cell-based assays and screens
• Participates in troubleshooting to implement data-driven solutions to cell engineering challenges
• Optimizes NGS library protocols to utilize new technologies
• Collaborates with other team members to achieve results

Basic Qualifications

• Bachelor’s Degree and 4+ years of academic and/or industry experience
• Or Master’s Degree and 2+ years of academic and/or industry experience

Preferred Qualifications

• Expertise across multiple gene editing platforms, including CRISPR/Cas9 and Perturb-seq, with direct experience in guide RNA design and verification of editing outcomes
• Experience designing and executing NGS library preparation workflows for gene editing applications and CRISPR screens with a focus on optimization for improved efficiency
• Skills in both large-scale and single-cell CRISPR screen-enabling studies, including molecular cloning and plasmid design, cell engineering, lentiviral transduction, flow cytometry, western blot/JESS, amplicon PCR, and large-format multilayer-flask tissue culture
• Familiarity with oncology drug discovery pipelines through design and execution of cell-based assays with a focus on genetic-perturbation strategies to interrogate novel therapeutic targets
• Ability to effectively communicate scientific findings to cross-functional teams
• Proficiency using scientific data analysis programs including GraphPad Prism, FlowJo, Microsoft Excel and PowerPoint, Geneious, Benchling, TapeStation Analysis Software