Senior Associate Scientist, Lab Automation Engineering

About the role

We seek a passionate, experienced, and creative Lab Automation Scientist or Engineer to drive implementation of automated and robotic solutions across our drug discovery platform. The candidate will become an integral member of a multidisciplinary team advancing novel RNAi therapeutic programs from target discovery through drug candidate lead selection. The primary objectives of the team are to develop highly scalable screening platforms and protocols to continually increase both throughput and decision-enabling content. The successful candidate will implement high-throughput workflows incorporating liquid- and plate-handling robotics in support of diverse application areas, including in vitro screening, ex-vivo sample processing, and high-throughput RNA-seq, including transcriptional profiling, spatial and single-cell applications.

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

Responsibilities

• Optimize, troubleshoot, and stabilize ex vivo sample-processing methods on the HighRes platform.
• Collaborate with cross-functional scientists to streamline ex vivo sample-processing workflows.
• Onboard and develop automated methods on the new PE JANUS and Beckman liquid-handling systems.
• Lead the transition of two manual workflows to robotic liquid-handling platforms.
• Perform maintenance and troubleshooting for the integrated HighRes system and associated processes.
• Serve as a liaison between external vendors and cross-functional site stakeholders.
• Train users and provide ongoing support for existing robotic platforms.

Qualifications

• S. or M.S. degree in Bioengineering, Engineering, Biochemistry, Molecular Biology, or related field
• 4+ years of hands-on experience operating and programming robotics platforms.
• Ability to understand diverse and complex workflows on liquid- and plate-handling systems, including the sources and statistical assessment of unwarranted assay variance
• Experience with liquid handlers and integrated platform such as PerkinElmer, HighRes Cellario, and Beckman Coulter.

Benefits

• Medical, dental, and vision coverage
• Life and disability insurance
• Lifestyle reimbursement program
• Flexible spending and health savings accounts
• 401(k) with a generous company match
• Paid time off
• Wellness days
• Holidays
• Two company-wide recharge breaks
• Generous family resources and leave

Pay

$93,500 - $126,500 USD