Senior Associate Scientist - Bioanalytical & Biomarker Technologies
BioSpace · Tarrytown, NY · 1 wk ago
Analyst$80k–$131k/yrFull-time
About the role
We are seeking a dynamic senior associate scientist to join bioanalytical & biomarker technologies group. The candidate will design and execute analytical and bioanalytical methods to support biotherapeutics discovery and preclinical development.
Responsibilities
- Design, execute, and troubleshoot LCMS and HPLC methods for analytical characterization of bioconjugates and bioanalytical quantification of therapeutics.
- Support a range of modalities including monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), siRNA/oligonucleotides, and endogenous biomarkers across diverse biological matrices.
- Perform end-to-end sample preparation (e.g., LLE, SPE, affinity capture, enzymatic digestion, homogenization) and operate LCMS/MS workflows from instrument setup to data analysis.
- Analyze and interpret results; summarize findings, propose next steps, and present data at internal meetings.
- Document experiments, methods, and results in electronic lab notebooks (ELNs) with clarity and rigor; contribute to SOPs and method documentation.
- Maintain instruments and general lab readiness; troubleshoot systems and ensure data integrity and instrument uptime.
- Evaluate and implement new platforms, workflows, and automation to improve throughput, sensitivity, and robustness.
- Prioritize effectively across multiple projects and timelines, collaborating closely with colleagues in discovery biology, DMPK/PKPD, and process/analytical teams.
Requirements
- BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Science or a related discipline with 3+ years hand-on experience.
- Experience in liquid chromatography and/or mass spectrometry is preferred, with the ability to execute, qualify and optimize analytical methods.
- Hands-on experience in sample preparation techniques (LLE, SPE, affinity capture, enzymatic digestion, homogenization, etc.)
- Detail-oriented, good interpersonal and effective technical communication skills (written and verbal).
- Ability to manage multiple projects in a fast-paced environment.
- Collaborative team player with a growth mindset to quickly adapt to evolving priorities and continuously learn to embrace new challenges.
- Previous exposure in bioanalysis of LC-MS based small molecule, oligonucleotides, biomarkers and biotherapeutics assay development is beneficial.
Qualifications
- BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Science or a related discipline.
- 3+ years of hands-on experience in liquid chromatography and/or mass spectrometry.
- Experience in sample preparation techniques (LLE, SPE, affinity capture, enzymatic digestion, homogenization, etc.).
- Detail-oriented, good interpersonal and effective technical communication skills (written and verbal).
- Ability to manage multiple projects in a fast-paced environment.
- Collaborative team player with a growth mindset to quickly adapt to evolving priorities and continuously learn to embrace new challenges.
- Previous exposure in bioanalysis of LC-MS based small molecule, oligonucleotides, biomarkers and biotherapeutics assay development is beneficial.
Skills
- Experience in designing and executing analytical and bioanalytical methods.
- Hands-on experience in sample preparation techniques.
- Ability to troubleshoot and optimize LCMS and HPLC methods.
- Effective communication skills (written and verbal).
- Ability to prioritize and manage multiple projects.
- Collaboration and adaptability to new challenges.
Benefits
- Competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.
Pay
- $80,300.00 - $131,100.00 annually
Schedule
- Full time