Senior Associate Scientist

About the role

We are seeking a highly motivated Senior Associate Scientist to join our Discovery Biotherapeutics organization in Cambridge, MA. This role will help advance high throughput, automated mammalian antibody expression capability within Discovery Biotherapeutics.

Responsibilities

• Strong background in molecular biology, including primer design, cloning, sequence analysis, and HT-PCR.
• Discovery-stage mammalian expression of antibodies and antibody-derived formats, including IgGs, fragments, and multispecific biologics in HT-plate based workflows.
• Experience with high-throughput, automated expression and purification workflows 4mL through 100mL scale and QC analytics for protein production including A280 protein concentration measurements, CE-SDS, SDS-PAGE, HT-anSEC, and endotoxin testing.
• Hands-on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7.
• Experience working with automation teams to integrate liquid handling, incubators, culture handling, and downstream processing steps.
• Interface with laboratory software platforms to ensure high-quality, traceable data generation compatible with computational and ML-driven discovery.
• Collaborate with AI/ML, binder discovery, molecular interaction, and functional assay teams to support binder discovery campaigns.

Requirements

• BS with 4+ years; or MS with 2+ years of pharmaceutical R&D or related industry experience.
• Molecular biology background with a strong understanding of cloning and high throughput fragment DNA generation.
• Experience with HTP-scale and mid-scale protein production and operating high-throughput, automated expression workflows.
• Hands-on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7.
• Experience in mammalian antibody expression, purification and ability to troubleshoot standard purification protocols and instrumentation.
• Strong understanding of HEK293, CHO, CFE or equivalent expression systems.

Qualifications & Experience

• The willingness to learn new workflows and work in mid-scale production / purification is desirable.

Benefits

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.