Senior Associate Scientist

Key Responsibilities

• Strong background in molecular biology ie primer design, cloning, sequence analysis, and HT-PCR is required.
• Discovery-stage mammalian expression of antibodies and antibody-derived formats, including IgGs, fragments, and multispecific biologics in HT-plate based workflows.
• Experience with high-throughput, automated expression and purification workflows: 4mL through 100mL scale and QC analytics for protein production including A280 protein concentration measurements, CE-SDS, SDS-PAGE, HT-anSEC, and endotoxin testing.
• Hands on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7.
• Experience in mammalian antibody expression, purification and ability to troubleshoot standard purification protocols and instrumentation.
• Strong understanding of HEK293, CHO, CFE or equivalent expression systems.
• Strong interpersonal skills and ability to work independently while influencing cross-functional discovery of biotherapeutics, biology, automation, and engineering teams.
• Excellent written and verbal communication skills and ability to work with a sense of urgency under tight deadlines.
• The willingness to learn new workflows and work in mid-scale production / purification is desirable.

Qualifications & Experience

• BS with 4+ years; or MS with 2+ years of pharmaceutical R&D or related industry experience.
• Molecular biology background with a strong understanding of cloning and high throughput fragment DNA generation.
• Experience with HTP-scale and mid-scale protein production and operating high-throughput, automated expression workflows.
• Hands on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7.
• Experience in mammalian antibody expression, purification and ability to troubleshoot standard purification protocols and instrumentation.
• A strong understanding of HEK293, CHO, CFE or equivalent expression systems.
• Strong interpersonal skills and ability to work independently while influencing cross-functional discovery of biotherapeutics, biology, automation, and engineering teams.
• Excellent written and verbal communication skills and ability to work with a sense of urgency under tight deadlines.
• The willingness to learn new workflows and work in mid-scale production / purification is desirable.