Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)
for section headings. Use - for any list of duties/requirements/benefits. Use
for prose.
We must not include job title heading. Not include Job ID etc.
We must preserve all substantive info; do not invent or summarize away detail. So we need to include all details from posting, but we can format them.
We need to avoid boilerplate: cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. So remove lines like "St. Jude is an Equal Opportunity Employer No Search Firms ..." and the paragraph about search firms, etc. Also remove "Explore our exceptional benefits! We are committed to a human-centered hiring experience..." maybe keep only if benefits specifics given, but none. So we can drop that.
Also remove "Learn more about our approach to AI." etc.
We need to keep the description about St. Jude, lab, mission, etc.
Let's extract substantive paragraphs:
Intro paragraph: "At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children."
Then description of Taosheng Chen Lab: "The Taosheng Chen Lab within our Department of Chemical Biology and Therapeutics is seeking a collaborative and innovative Scientist or Senior Scientist with expertise in cell biology, molecular biology, and/or chemical biology to lead research efforts to develop and characterize the mechanisms of action of novel chemical probes—including agonists, antagonists, and degraders—targeting the nuclear receptors PXR and CAR. The successful candidate will independently design and execute studies, generate high-quality datasets to test scientific hypotheses, and integrate findings across multiple disciplines. The candidate will work closely with in-house structural biologists and medicinal chemists to generate complementary data and advance projects, and will take a leading role in organizing and writing multidisciplinary manuscripts. The Chen Laboratory leverages multidisciplinary approaches to investigate the chemical regulation of nuclear receptors, with the overarching goal of elucidating nuclear receptor-driven transcriptional networks and developing innovative therapeutic strategies to combat drug resistance and tumorigenesis. Using integrated cellular, molecular, and chemical biology approaches, our research is closely aligned with structural biology and medicinal chemistry, enabling the successful execution of high-impact, collaborative studies. This synergistic framework has led to publications in leading journals, including Nature Communications (2017, 2024, 2025) and PNAS (2023), highlighting our contributions to advancing the understanding and therapeutic targeting of nuclear receptor signaling."
Then: "The successful candidate will have a strong track record of high-quality research and publication in peer-reviewed journals. Relevant experience should include several of the following: DNA: cloning, plasmid construction, and related molecular biology techniques RNA: RNA isolation, gene expression analysis, and transcriptional profiling Proteins: Western blotting, protein–compound interactions, protein–protein interactions, and/or proteomic profiling Small molecules: experience evaluating the cellular activity, mechanism of action, and/or pharmacology of small-molecule compounds Structural biology: a basic understanding of protein crystal structures and ligand–protein interactions is essential for effective collaboration with structural biologists Medicinal chemistry: a basic understanding of small-molecule structures and structure–activity relationships is important for meaningful collaboration with medicinal chemists Murine studies experience is a plus"
Then "Candidate Profile Priorities Our search will focus on candidates with: Strong cell and molecular biology expertise with exposure to chemical biology Experience evaluating small-molecule mechanisms of action An understanding of structural biology and medicinal chemistry concepts A demonstrated record of impactful publications, particularly in high-quality journals Academic and industry backgrounds will both be considered"
Then "Research Focus & Key Projects The selected candidate will play a leading role in advancing the laboratory's efforts to understand and therapeutically target the nuclear receptors PXR and CAR through multidisciplinary approaches spanning cell biology, molecular biology, chemical biology, structural biology, and medicinal chemistry. Current projects include: Developing and characterizing novel chemical probes, including agonists, antagonists, and degraders, targeting nuclear receptors. Investigating the mechanisms of action of small molecules and protein degraders, including PROTAC-based approaches. Defining how chemical modulation of PXR and CAR influences transcriptional networks, drug metabolism, chemotherapy response, and tumorigenesis. Collaborating with structural biologists to understand ligand-protein interactions and guide structure-based discovery efforts. Leading the integration of multidisciplinary findings into manuscripts, publications, and future grant-supported research initiatives."
Then "Job Responsibilities:" list bullet points.
Then "Minimum Education: Bachelor's degree in relevant scientific area is required A PhD in cell biology, molecular biology, chemical biology, pharmacology, or a related field, together with productive postdoctoral research experience, is strongly preferred"
Then "Senior Scientist Minimum Experience: Ten (10) years relevant work experience is required Eight (8) years of relevant work experience is required with a Master's degree Five (5) years of relevant work experience is required with a PhD"
Then "Scientist Minimum Experience: Eight (8) years of relevant work experience is required Six (6) years of relevant work experience is required with a Master's degree Three (3) years of relevant work experience is required with a PhD"
Then "A reasonable estimate of the current salary range is $104,000 - $186,160 per year Scientist Minimum Experience: ... A reasonable estimate of the current salary range is $86,320 - $154,960 per year"
Then later: "The selected candidate will be appointed at the Scientist or Sr. Scientist level, based on their experience, demonstrated scientific independence, technical expertise, and leadership achievements. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)."
We need to avoid duplication. We'll include Pay section with the ranges: maybe combine both Scientist and Senior Scientist ranges.
We need to ensure we don't include filler like "commensurate with experience". Not present.
We need to output only HTML fragment.
Let's decide sections:
- About the role: include intro paragraph + lab description + mission + research focus maybe.
- Responsibilities: list from Job Responsibilities.
- Requirements: include Minimum Education, Senior Scientist Minimum Experience, Scientist Minimum Experience, Candidate Profile Priorities maybe.
- Qualifications: maybe the relevant experience list (DNA, RNA, etc.) and skills.
- Skills: maybe the list of relevant experience (DNA, RNA, proteins, small molecules, structural biology, medicinal chemistry, murine studies). Could also include "Experience evaluating small-molecule mechanisms of action" etc.
But we need to avoid duplication. Let's think: The posting has sections: "Relevant experience should include several of the following:" which is a list of skills. Then "Candidate Profile Priorities" which is another list. Then "Research Focus & Key Projects" which is more description.
We could combine Requirements (education + experience) and Qualifications (skills). But we need to follow instruction: use sections only when posting has real specific content. We can have multiple sections.
Let's define:
About the role
... intro + lab description + research focus ...
Responsibilities
... list items ...
Requirements
Minimum Education: ...
Senior Scientist Minimum Experience: ...
Scientist Minimum Experience: ...
Candidate Profile Priorities: ...
maybe as .
Skills
list of relevant experience (DNA, RNA, Proteins, Small molecules, Structural biology, Medicinal chemistry, Murine studies)
Pay
Salary ranges: Scientist: $86,320 - $154,960 per year; Senior Scientist: $104,000 - $186,160 per year.
maybe also note overall range.
We should not include Benefits or Schedule.
Check for any duplicated lines: we need to avoid repeating same info multiple times. We'll consolidate.
Now we need to preserve all substantive information. Let's ensure we include all details from the posting.
Let's extract each piece.
Intro paragraph: At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.
Lab description: The Taosheng Chen Lab within our Department of Chemical Biology and Therapeutics is seeking a collaborative and innovative Scientist or Senior Scientist with expertise in cell biology, molecular biology, and/or chemical biology to lead research efforts to develop and characterize the mechanisms of action of novel chemical probes—including agonists, antagonists, and degraders—targeting the nuclear receptors PXR and CAR. The successful candidate will independently design and execute studies, generate high-quality datasets to test scientific hypotheses, and integrate findings across multiple disciplines. The candidate will work closely with in-house structural biologists and medicinal chemists to generate complementary data and advance projects, and will take a leading role in organizing and writing multidisciplinary manuscripts. The Chen Laboratory leverages multidisciplinary approaches to investigate the chemical regulation of nuclear receptors, with the overarching goal of elucidating nuclear receptor-driven transcriptional networks and developing innovative therapeutic strategies to combat drug resistance and tumorigenesis. Using integrated cellular, molecular, and chemical biology approaches, our research is closely aligned with structural biology and medicinal chemistry, enabling the successful execution of high-impact, collaborative studies. This synergistic framework has led to publications in leading journals, including Nature Communications (2017, 202
for prose. We must not include job title heading. Not include Job ID etc. We must preserve all substantive info; do not invent or summarize away detail. So we need to include all details from posting, but we can format them. We need to avoid boilerplate: cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. So remove lines like "St. Jude is an Equal Opportunity Employer No Search Firms ..." and the paragraph about search firms, etc. Also remove "Explore our exceptional benefits! We are committed to a human-centered hiring experience..." maybe keep only if benefits specifics given, but none. So we can drop that. Also remove "Learn more about our approach to AI." etc. We need to keep the description about St. Jude, lab, mission, etc. Let's extract substantive paragraphs: Intro paragraph: "At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children." Then description of Taosheng Chen Lab: "The Taosheng Chen Lab within our Department of Chemical Biology and Therapeutics is seeking a collaborative and innovative Scientist or Senior Scientist with expertise in cell biology, molecular biology, and/or chemical biology to lead research efforts to develop and characterize the mechanisms of action of novel chemical probes—including agonists, antagonists, and degraders—targeting the nuclear receptors PXR and CAR. The successful candidate will independently design and execute studies, generate high-quality datasets to test scientific hypotheses, and integrate findings across multiple disciplines. The candidate will work closely with in-house structural biologists and medicinal chemists to generate complementary data and advance projects, and will take a leading role in organizing and writing multidisciplinary manuscripts. The Chen Laboratory leverages multidisciplinary approaches to investigate the chemical regulation of nuclear receptors, with the overarching goal of elucidating nuclear receptor-driven transcriptional networks and developing innovative therapeutic strategies to combat drug resistance and tumorigenesis. Using integrated cellular, molecular, and chemical biology approaches, our research is closely aligned with structural biology and medicinal chemistry, enabling the successful execution of high-impact, collaborative studies. This synergistic framework has led to publications in leading journals, including Nature Communications (2017, 2024, 2025) and PNAS (2023), highlighting our contributions to advancing the understanding and therapeutic targeting of nuclear receptor signaling." Then: "The successful candidate will have a strong track record of high-quality research and publication in peer-reviewed journals. Relevant experience should include several of the following: DNA: cloning, plasmid construction, and related molecular biology techniques RNA: RNA isolation, gene expression analysis, and transcriptional profiling Proteins: Western blotting, protein–compound interactions, protein–protein interactions, and/or proteomic profiling Small molecules: experience evaluating the cellular activity, mechanism of action, and/or pharmacology of small-molecule compounds Structural biology: a basic understanding of protein crystal structures and ligand–protein interactions is essential for effective collaboration with structural biologists Medicinal chemistry: a basic understanding of small-molecule structures and structure–activity relationships is important for meaningful collaboration with medicinal chemists Murine studies experience is a plus" Then "Candidate Profile Priorities Our search will focus on candidates with: Strong cell and molecular biology expertise with exposure to chemical biology Experience evaluating small-molecule mechanisms of action An understanding of structural biology and medicinal chemistry concepts A demonstrated record of impactful publications, particularly in high-quality journals Academic and industry backgrounds will both be considered" Then "Research Focus & Key Projects The selected candidate will play a leading role in advancing the laboratory's efforts to understand and therapeutically target the nuclear receptors PXR and CAR through multidisciplinary approaches spanning cell biology, molecular biology, chemical biology, structural biology, and medicinal chemistry. Current projects include: Developing and characterizing novel chemical probes, including agonists, antagonists, and degraders, targeting nuclear receptors. Investigating the mechanisms of action of small molecules and protein degraders, including PROTAC-based approaches. Defining how chemical modulation of PXR and CAR influences transcriptional networks, drug metabolism, chemotherapy response, and tumorigenesis. Collaborating with structural biologists to understand ligand-protein interactions and guide structure-based discovery efforts. Leading the integration of multidisciplinary findings into manuscripts, publications, and future grant-supported research initiatives." Then "Job Responsibilities:" list bullet points. Then "Minimum Education: Bachelor's degree in relevant scientific area is required A PhD in cell biology, molecular biology, chemical biology, pharmacology, or a related field, together with productive postdoctoral research experience, is strongly preferred" Then "Senior Scientist Minimum Experience: Ten (10) years relevant work experience is required Eight (8) years of relevant work experience is required with a Master's degree Five (5) years of relevant work experience is required with a PhD" Then "Scientist Minimum Experience: Eight (8) years of relevant work experience is required Six (6) years of relevant work experience is required with a Master's degree Three (3) years of relevant work experience is required with a PhD" Then "A reasonable estimate of the current salary range is $104,000 - $186,160 per year Scientist Minimum Experience: ... A reasonable estimate of the current salary range is $86,320 - $154,960 per year" Then later: "The selected candidate will be appointed at the Scientist or Sr. Scientist level, based on their experience, demonstrated scientific independence, technical expertise, and leadership achievements. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)." We need to avoid duplication. We'll include Pay section with the ranges: maybe combine both Scientist and Senior Scientist ranges. We need to ensure we don't include filler like "commensurate with experience". Not present. We need to output only HTML fragment. Let's decide sections: - About the role: include intro paragraph + lab description + mission + research focus maybe. - Responsibilities: list from Job Responsibilities. - Requirements: include Minimum Education, Senior Scientist Minimum Experience, Scientist Minimum Experience, Candidate Profile Priorities maybe. - Qualifications: maybe the relevant experience list (DNA, RNA, etc.) and skills. - Skills: maybe the list of relevant experience (DNA, RNA, proteins, small molecules, structural biology, medicinal chemistry, murine studies). Could also include "Experience evaluating small-molecule mechanisms of action" etc. But we need to avoid duplication. Let's think: The posting has sections: "Relevant experience should include several of the following:" which is a list of skills. Then "Candidate Profile Priorities" which is another list. Then "Research Focus & Key Projects" which is more description. We could combine Requirements (education + experience) and Qualifications (skills). But we need to follow instruction: use sections only when posting has real specific content. We can have multiple sections. Let's define:
About the role
... intro + lab description + research focus ...
Responsibilities
- ... list items ...
Requirements
Minimum Education: ...
Senior Scientist Minimum Experience: ...
Scientist Minimum Experience: ...
Candidate Profile Priorities: ...
maybe as- .
Skills
- list of relevant experience (DNA, RNA, Proteins, Small molecules, Structural biology, Medicinal chemistry, Murine studies)
Pay
Salary ranges: Scientist: $86,320 - $154,960 per year; Senior Scientist: $104,000 - $186,160 per year.
maybe also note overall range. We should not include Benefits or Schedule. Check for any duplicated lines: we need to avoid repeating same info multiple times. We'll consolidate. Now we need to preserve all substantive information. Let's ensure we include all details from the posting. Let's extract each piece. Intro paragraph: At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. Lab description: The Taosheng Chen Lab within our Department of Chemical Biology and Therapeutics is seeking a collaborative and innovative Scientist or Senior Scientist with expertise in cell biology, molecular biology, and/or chemical biology to lead research efforts to develop and characterize the mechanisms of action of novel chemical probes—including agonists, antagonists, and degraders—targeting the nuclear receptors PXR and CAR. The successful candidate will independently design and execute studies, generate high-quality datasets to test scientific hypotheses, and integrate findings across multiple disciplines. The candidate will work closely with in-house structural biologists and medicinal chemists to generate complementary data and advance projects, and will take a leading role in organizing and writing multidisciplinary manuscripts. The Chen Laboratory leverages multidisciplinary approaches to investigate the chemical regulation of nuclear receptors, with the overarching goal of elucidating nuclear receptor-driven transcriptional networks and developing innovative therapeutic strategies to combat drug resistance and tumorigenesis. Using integrated cellular, molecular, and chemical biology approaches, our research is closely aligned with structural biology and medicinal chemistry, enabling the successful execution of high-impact, collaborative studies. This synergistic framework has led to publications in leading journals, including Nature Communications (2017, 202