Scientist / Senior Scientist, Metabolomics Group Lead

Responsibilities

Collaborate with cross-functional scientists to define project objectives, assess feasibility, and establish clear deliverables and timelines
Execute and supervise sample preparation workflows for steady-state metabolomics and lipidomics
Operate, maintain, and troubleshoot LC-MS instrumentation (e.g., Thermo Exploris 240, SCIEX 7500, Vanquish HPLC) to ensure optimal performance and minimal downtime
Optimize and adapt extraction protocols to support analysis of diverse and challenging biological samples
Process and analyze raw datasets with software (e.g. Skyline, Compound Discoverer), and coordinate with bioinformatics teams to ensure accurate data processing, quality control, and efficient project execution
Maintain accurate and up-to-date project tracking and documentation in systems, such as Benchling, and shared project management tools
Communicate project status, timelines, and risks effectively to internal stakeholders and leadership

Requirements

PhD (or equivalent experience) in metabolomics, lipidomics, analytical chemistry, biochemistry, or a related discipline.
>6 years of hands-on experience with both HRAM and LRMS preferably with Orbitrap Exploris and SCIEX triple quadrupole mass spectrometry platforms.
Strong experimental design and problem-solving skills, with experience performing sample preparation of cells, tissues, and biofluids.
Demonstrated experience with mentoring and project management, including managing collaborations with scientists with diverse training backgrounds.

Qualifications

Preferred qualifications include:
Experience developing new methods for analysis of metabolites/lipids of interest
Prior experience in Metabolite Identification and trapping in the context of drug metabolism
Experience performing large-scale discovery studies of > 1,000 samples
Experience designing and interpreting complex isotope tracing experiments (e.g., metabolic flux analysis)
Experience integrating metabolomics/lipidomics with other omics, including proteomics and transcriptomics

Benefits

Redwood City, California
Scientist II: $156,800- $201,000
Senior Scientist : $172,400- $221,000

Pay

Salary Range: Redwood City, California Scientist II: $156,800- $201,000
Senior Scientist : $172,400- $221,000

Schedule

This is an on-site role

Company Information

Equal Opportunity Employer
Altos Labs values collaboration and scientific excellence. We believe that a culture of belonging is foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.