Scientist/Senior Scientist, Bioanalytical Sciences

About the role

The Bioanalytical Sciences team at Company Addition Therapeutics is seeking a dynamic and highly motivated Scientist / Senior Scientist to contribute to the development and execution of various bioanalytical assays for preclinical translation and development. This role involves hands-on research to evaluate PRINT™-delivered payloads in disease-relevant contexts, guiding candidate selection and advancing therapeutic programs toward clinical development.

Responsibilities

• Design, develop, validate, and execute in vitro, cell-based, and ex vivo assays to evaluate the efficacy, pharmacology, and delivery of various payloads using PRINT™ technology.
• Develop and execute pharmacodynamic assays to measure transgene expression, protein production and secretion, enzymatic activity, receptor engagement, and downstream biological responses.
• Develop and run cell-based functional assays to evaluate therapeutic efficacy across obesity and other metabolic diseases.
• Establish assays using primary cells, immortalized cell lines, and tissue-derived samples to support translational studies.
• Collaborate with in vivo pharmacology teams to analyze plasma and tissue samples from rodent and non-human primate studies.
• Ensure accurate and reliable results through meticulous hands-on execution and record-keeping.
• Support PK/PD characterization by generating quantitative bioanalytical data to inform dose selection and mechanism of action.
• Contribute to assay transfer, qualification, documentation, and implementation of best laboratory practices.
• Collaborate with internal teams and partners to integrate and optimize current and new assay technologies and methodologies.
• Analyze experimental data, interpret results, and present findings in team meetings.
• Contribute to troubleshooting and refining assay protocols.
• Stay up to date with relevant scientific literature and emerging technologies.
• Provide input on potential improvements or innovations in assay development and genomic medicine applications.
• Contribute to data packages supporting IND-enabling studies, partnership diligence, and investor milestones.

Requirements

• PhD in molecular biology, biochemistry, pharmacology, cell biology, or a closely related field (relevant industry experience considered in lieu of Ph.D.).
• Proficiency across standard molecular/biochemical assay platforms: ELISA, MSD, AlphaLISA, ddPCR, qPCR, Western blot, flow cytometry, and microscopy.
• Experience in mammalian cell culture to support cell-based assays.
• Ability to independently design experiments, troubleshoot, and interpret data.
• A clear and organized scientific communicator, comfortable presenting data to cross-functional audiences.

Preferred

• Familiarity with obesity biology, metabolic disease, GPCR pharmacology.
• Experience with genomic medicines, mRNA, or RNA-based therapeutic modalities.
• Exposure to NHP or translational PK/PD study design.
• Familiarity with HTS or automated liquid handling platforms.