Scientist, In Vitro Services

About the role

Pacific BioLabs is an independent CRO providing cGMP/GLP testing in toxicology, biocompatibility, pharmacology, analytical chemistry, and microbiology. We are currently seeking energetic scientists and professionals to support our clients in the pharmaceutical, biotech, and medical device fields. Join us in our mission to improve public health through science!

PBL has an immediate opportunity for an In Vitro Scientist within the Analytical Services team, specializing in In Vitro and Cellular Sciences. The In Vitro Scientist will play a key role in the execution and analysis of in vitro cellular assays in support of non-clinical, GLP, and cGMP studies for PBL clients. This position will work closely with scientists throughout the Analytical Services department and collaborate with colleagues in In Vivo and Microbiology Services to support integrated testing programs. The ideal candidate will be self-driven, eager to learn new techniques, and highly organized.

Responsibilities

• Leverage significant experience building and working with in vitro/cell-based models to expand PBL service offerings.
• Work independently and in collaboration with other scientists in the company to identify, design, validate, and qualify cellular assays in support of client needs.
• Work with a diverse range of cell-based models, including primary and immortal mammalian cells, transfected cell lines, over-expressing cell lines, etc.
• Regularly apply a broad range of approaches such as stable/transient transfections, protein/target expression and characterization, and downstream signaling or functional pathway endpoints.
• Develop and implement new techniques and procedures within the In Vitro Services Department in support of client testing needs.
• Possess strong collaborative, written and verbal communication skills for both internal and client-based discussions/projects.
• Serve as a resource to clients for experimental, scientific, and regulatory expertise related to specific studies or areas of testing.
• Serve as a Study Director (GLP) or Lead Analyst (cGMP) for a variety of in vitro studies including but not limited to cytotoxicity, target-engagement, USP/ISO compendial tests, potency testing, in vivo/ex vivo /in vitro bridging studies, etc. This includes serving as the primary client contact in the evaluation of new projects, experimental design, execution, data collection, and reporting.
• Ensure that all reasonable client requests pertaining to the conduct of a given test are met in a timely and ultimately effective manner.
• Consistently operate in compliance with cGMP/GLP regulations as these pertain to work performed in the in vitro laboratory.

Qualifications

• Advanced degree (M.S., Ph.D. or equivalent with 2+ years) in a science-related field (e.g., Biology, Chemistry, etc.). Undergraduate degree (B.S. or equivalent) with significant experience (10-15+ years) may substitute for an advanced degree.
• Experience in the development, optimization, and execution of cellular assays employing multiple techniques including tissue culture, cell growth and proliferation, cell transfection, gene expression, cytokine analysis, Elisa, ELISpot, and immunological procedures highly desired.
• Experience working with minimal supervision in a laboratory setting with a broad understanding and applied knowledge of cellular/molecular biology.
• Demonstrated track record in functional assay development a plus.
• Proficient with BSL-2 and cell-culture laboratory concepts/systems and use of laboratory equipment.
• Solid grasp of advanced scientific principles and language relevant to in vitro/cellular testing.
• Well-developed math skills.
• Language aptitude sufficient to read, write and follow general laboratory SOPs and specific study protocols. Must be able to accurately describe test procedures and summarize test results.
• Advanced problem-solving/troubleshooting skills.
• Proficient and/or willing to be trained in cGMP/GLP documentation.
• Proficient computer skills.
• Good listening skills required. Must be able to provide clear and concise directions.
• Must be able to work well with persons from diverse backgrounds and education and skills, and work as part of a team.
• Job requires mobile use of hands, arms, and legs. Reasonable accommodations will be made for persons with disabilities.
• Must be willing to work outside normal business hours, including weekends and holidays.
• Must be willing to work with hazardous materials.

Pay

The pay range for this position is $85,000 to $100,000 annually. The base pay offered will take into account internal equity and also may vary depending on the candidate's job-related knowledge, skills, and experience among other factors.

Benefits

This position will be eligible for medical, dental, vision, life insurance, 401k, and other benefits.