Scientist III - Global Flow

About the role

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Scientist at KCAS Bio is the role for you. When you work as a Scientist III in the Flow Cytometry group at KCAS, you get to further our mission by applying your knowledge in bioanalytical and scientific principles to independently execute studies and support the development, qualification, and validation of flow cytometry and cell-based assays. You will utilize your strong scientific foundation to assess assay performance, interpret data, troubleshoot complex technical issues, and ensure the integrity and quality of study results. Our Flow Cytometry team utilizes advanced instrumentation and analytical techniques to support bioanalytical testing in drug discovery, preclinical, and clinical studies, including immunophenotyping, cell-based assays, and biomarker analysis in biological matrices. KCAS Bio is a fast-growing contract research organization (CRO) headquartered in Kansas City, pioneering the latest drug development in both human and animal health fields. Demand for our expertise is growing and so is our need for great people to work in nimble, empowered teams committed to one another’s growth. At KCAS Bio, we advance both great science AND great people.

Responsibilities

• Independently execute and support flow cytometry studies from study setup through data generation, analysis, and reporting
• Develop, optimize, qualify, validate, and transfer flow cytometry methods in support of preclinical and clinical studies
• Design and optimize multiparametric flow cytometry panels, including selection and evaluation of antibody clones, fluorochromes, titrations, controls, sample matrices, and gating strategies
• Perform flow cytometry sample preparation, staining, data acquisition, analysis, and interpretation
• Operate conventional and spectral flow cytometry instrumentation, including platforms such as Cytek Aurora and BD flow cytometers
• Develop and optimize assays utilizing biological matrices such as whole blood, fresh or cryopreserved PBMCs, bone marrow, tissue, and cell lines
• Analyze and interpret complex flow cytometry data and prepare data summaries and presentations for internal and client reviews
• Evaluate assay performance characteristics including precision, accuracy, sensitivity, selectivity, stability, robustness, linearity, and other applicable parameters
• Troubleshoot complex assay, sample, reagent, instrumentation, and data analysis issues and develop scientifically sound solutions
• Apply knowledge of immunology and cell biology to immunophenotyping, biomarker, and functional cellular assay applications
• Support study activities involving applications such as immune profiling, receptor occupancy, target engagement, intracellular marker analysis, proliferation, and other functional cellular endpoints as applicable
• Ensure proper sample identification, handling, processing, storage, and tracking throughout study execution
• Maintain accurate and complete documentation in accordance with study protocols, SOPs, and applicable regulatory and quality requirements
• Review and interpret scientific data to identify trends, inconsistencies, and potential risks to study execution or data quality
• Prepare and review protocols, study documentation, data summaries, and reports
• Communicate scientific findings, study progress, technical challenges, and recommendations to project teams, management, and clients as appropriate
• Provide technical guidance and training to less experienced scientific staff
• Collabor