Scientist III, Antibody Engineering

About the Company

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference (RNAi) mechanism to induce rapid, deep, and durable knockdown of target genes. RNAi is a natural cellular process that inhibits gene expression, affecting protein production. Arrowhead’s RNAi-based therapeutics leverage this pathway to address diseases with a genetic basis, often characterized by protein overproduction. The company’s RNAi technologies enable the pursuit of disease targets across virtually any therapeutic area, including those not addressable by small molecules and biologics.

Arrowhead is leading the field in expanding RNAi applications beyond the liver, with a clinical pipeline targeting liver and lung diseases and a promising preclinical pipeline. Headquartered in Pasadena, CA, the company has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI. Employees are nimble, science-driven innovators collaborating to bring new therapies to patients in need.

About the Role

We are seeking a highly motivated and skilled Molecular Biologist to join our dynamic research team in Discovery Chemistry. The successful candidate will play a key role in antibody engineering to support platform development and drug delivery initiatives. This position requires extensive hands-on experience in phage display, antibody engineering, and antibody characterization, supported by a strong foundation in molecular biology.

Responsibilities

• Design and construct mutant phage libraries for antibody affinity maturation or humanization.
• Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design.
• Express and purify recombinant antibodies using bacterial and mammalian expression systems.
• Perform binding, specificity, and in vitro functional assays.
• Collaborate with cross-functional project teams to advance lead antibodies through drug development stages.
• Maintain accurate documentation and present findings at internal meetings.

Requirements

• Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
• Hands-on experience with phage display technology for antibody engineering.
• Proficiency in molecular cloning, PCR, and mutagenesis.
• Experience with antibody expression and purification using E. coli, HEK293, and CHO systems.
• Strong analytical and problem-solving skills, with the ability to troubleshoot experiments independently.
• Excellent record-keeping, communication, and collaboration skills.
• Proven ability to adapt to a fast-paced and evolving research environment.
• Track record of scientific productivity, including peer-reviewed publications, conference presentations, or patents.

Additional experience in molecular biology and/or antibody discovery is highly desirable. Industry or postdoctoral experience is preferred.

Pay

California pay range: $120,000–$130,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefits package.

Candidates must have current, valid authorization to work in the country where this role is located.