Scientist II/Senior Scientist, Protein Sciences – Cell Binding Assays

Responsibilities

• Design and generate stable and transient cell lines expressing target antigens (including membrane receptors and other challenging targets) to support antibody discovery and characterization campaigns.
• Develop and maintain cell lines optimized for whole-cell panning and display-based selection workflows.
• Develop, optimize, and qualify cell-based binding assays (flow cytometry / FACS, cell ELISA, and equilibrium binding formats) to characterize antibody-type molecules across a range of formats.
• Adapt assays to higher-throughput formats to increase screening capacity across discovery campaigns.
• Work at the cutting edge of innovation in cell engineering to workflows for characterization of binder libraries.

Required Qualifications

• PhD in cell biology, immunology, biochemistry, molecular biology, or a related field, with 3+ years of relevant post-graduate experience (or MS with 8+ years) in a biotech/pharma discovery setting.
• Expertise in mammalian cell engineering and cell line development.
• Demonstrated experience with FACS and general assay development.
• Strong practical knowledge of antibody characterization concepts — on-cell affinity/avidity, specificity and selectivity, epitope binning, and competition/blocking assays.
• Proven ability to work independently, design rigorous experiments, troubleshoot complex problems, and interpret data with sound scientific judgment.
• Track record of collaborating cross-functionally and communicating results clearly to project teams.

Preferred Qualifications

• Direct experience with whole-cell panning and display-based selection (phage and/or yeast display), including negative-selection/depletion strategies against native membrane targets.
• Familiarity with a range of antibody formats.
• Experience with orthogonal biophysical binding methods (SPR/BLI, e.g. Biacore or Octet) to complement cell-based data.
• Experience adapting assays to higher-throughput or automated platforms.

Pay

Base Salary Range: $125,000 - $175,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

Benefits

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Schedule

Not specified

Qualifications

Not specified

Skills

Not specified

Benefits

Not specified

Schedule

Not specified

Application Instructions

Not specified