Scientist, Ligand Binding Assays

About the role

The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Scientist, specializing in ligand binding assays to quantify oligos, proteins, peptides, and antibodies. This individual will be responsible for supporting fit-for-purpose methods across various technologies, such as hybridization ELISA, ELISA, MSD, FACS, ELLA, and Quanterix, to support early through late-stage drug development programs to inform on target engagement, pharmacodynamics (PD), pharmacokinetics (PK), mechanism of action, and safety, to advance RNAi therapeutic development.

Responsibilities

• Design, develop, and implement ligand binding assays (ELISA, MSD, Quanterix), in a variety of biological matrices to support the analysis of drug PK, PD & biomarker, with minimal direction.
• Independently and reliably conduct non-GLP sample analysis to support all Alnylam’s RNAi therapeutic development from early to late stages.
• Aid in critically reviewing and troubleshooting internal and external ligand-binding assays.
• Aid associate scientists in method optimization and troubleshooting assays.
• Help implement and maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data.
• Maintain laboratory notebooks, perform data analysis and QC, and communicate results to a broad and/or specialized team.
• Understand project goals and ability to make decisions independently.
• Apply an in-depth understanding of the technologies and intended use of the results to aid in interpretation of data.
• Independently prepare presentations and effectively communicate with broader matrixed teams to demonstrate subject matter leadership.
• Independently author SOPs and reports for LBA methods and support method transfers to CROs, as needed.
• Research and implement new technologies to improve assay performance or address specific questions.
• Investigate areas for automation to increase quality or efficiency.

Qualifications

• Ph.D. in biochemistry, chemistry, molecular/cell biology, or related field with 0+ years of relevant industry experience or exceptional non-PhD (Masters degree with 8+ years, or Bachelors degree with 10+ years of industry experience).
• Possesses in-depth knowledge, hands on experience, and technical expertise on ligand binding assays. Knowledge of Liquid Handlers/Automated ELISA (e.g., Biomek), FACS and LCMS methods is a plus.
• Knowledge of regulatory expectations for bioanalytical method validation or previous experience working in a bioanalytical GLP or non-GLP environment is preferred.
• Demonstrates a solid understanding of disease biology and the drug development process to enable design and implementation of assays that are fit for intended use.
• Track record in preparing conference presentations, publications in peer reviewed journals, or industry and regulatory white papers.
• Demonstrates strong problem solving ability and adaptability, in and out of their comfort zone.
• Detail-oriented with exceptional organizational skills, and the ability to handle multiple projects, and thrive in a fast-paced, team-oriented environment.
• Has strong interpersonal skills to enable collaboration with cross-functional teams.
• Possesses excellent verbal and written communication skills.

Pay

$110,400.00 - $165,600.00