Scientist II, Biologics Developability

Job Summary

The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development Org. The team identifies biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection and characterizes key CMC attributes for biologic drug development. We seek a motivated scientist to join this dynamic team.

location

Worcester, Massachusetts

job type

Contract

salary

$45.00 - 50.76 per hour

work hours

9 to 5

education

Bachelor's degree or equivalent experience

Responsibilities

• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.
• Conduct liquid chromatography-based characterization of biologic drug candidates (size exclusion, ion exchange, and reverse phase).
• Execute experimental protocols, collect results, and perform data analysis carefully and independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Qualifications

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3-5 (BS) or 1-2 years (MS), or Ph.D. with 0+ years of biopharmaceutical industry experience.
• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping) and data processing is required.
• Experience with liquid chromatography methods commonly used for characterization of biologic proteins is required.
• Experience with liquid handling robots and their programming would be highly beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated.

Skills

• Chemistry
• Chromatography
• High Pressure Liquid Chromatography (HPLC)
• Liquid Chromatography (LC)
• Good Laboratory Practices (GLP)
• Good Manufacturing Practices (GMP)
• Chemistry Manufacturing and Controls (CMC)

Benefits

• Medical
• Prescription
• Dental
• Vision
• AD&D
• Life Insurance
• Short-term disability
• 401K plan