Scientist II
About the role
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. We are seeking a motivated, hands-on Scientist I/II with both in vivo and in vitro research experience, including work in iPSC-derived cardiomyocytes and other primary cell systems, engineered tissues, and animal disease models. The ideal candidate is a rigorous, detail-oriented investigator who thrives in a hands-on role and contributes to compound efficacy characterization through preclinical drug development within a highly collaborative, multidisciplinary environment. The level of the role (Scientist I or Scientist II) will be determined based on the candidate’s experience, demonstrated independence, and degree of project and target ownership.
Responsibilities
- Perform hands-on rodent work (mouse and rat) - handling, dosing, tissue collection, and disease model support in compliance with IACUC guidelines.
- Isolate primary cells from tissues and perform ex vivo experiments (e.g., Langendorff/perfused heart, measures of contractility).
- Perform molecular and biochemical assays (Western blot, qPCR, immunostaining/IF, ELISA, enzyme-based) to quantify markers of disease biology and target engagement.
- Culture and run functional experiments on iPSC-derived cardiomyocytes, primary cardiomyocytes, other cell types, and engineered heart tissues (EHTs) as needed.
- Independently develop, optimize, and troubleshoot cell-based and molecular