Scientist II, Antisense/siRNA and Peptide Purification

About This Role

At Biogen, we are advancing science to transform patients’ lives. We are seeking a highly motivated Scientist II to join our Technical Development team in Cambridge, MA, focused on oligonucleotide (Antisense/siRNA) and Peptide Purification. This is an exciting opportunity to design and develop robust, scalable purification processes that directly impact clinical and commercial therapeutics. You will play a key role in advancing next-generation modalities by bridging early development with manufacturing, working in a highly collaborative, cross-functional environment. Your work will contribute to building state-of-the-art platform processes that improve product quality, scalability, and efficiently enabling delivery of innovative therapies to patients.

Who We Are

We are a team of chemists and chemical engineers engaged in the design of innovative processes which supply new medicines to patients. We focus on developing safe, economical, sustainable, cost-effective, and robust processes to support clinical trials and the launch of new medicines across various drug modalities. We are driven by first principles science, data-driven decision-making, and collaborative teamwork.

What You’ll Do

• Design, develop, and scale purification processes across development stages (early development through commercial)
• Apply data-driven approaches (e.g., DoE) to characterize processes and define robust control strategies
• Lead or support technology transfer of processes into GMP manufacturing
• Troubleshoot process challenges and drive continuous improvement in process performance
• Collaborate with Manufacturing, Analytical, Quality, Non-Clinical, and Regulatory teams to enable program advancement
• Author technical reports and contribute to CMC sections of regulatory filings and respond to agency questions

Who You Are

You are a hands-on purification scientist who thrives in a dynamic, team-oriented environment. You possess strong analytical skills, and a keen ability to apply statistical analysis to complex data. You have a natural curiosity and a passion for process development. Your technical writing and communication skills are excellent, enabling you to effectively present technical data and contribute to regulatory documentation.

Required Skills

• Ph.D. degree in chemical engineering, chemistry, or a related science with 0-3 years of experience
• Master’s degree in chemical engineering, chemistry, or a related science with 4+ years of experience in pharmaceutical or biotech settings
• Bachelor’s degree in chemical engineering, chemistry, or a related science with 6+ years of relevant experience in pharmaceutical or biotech settings
• Experience in purification process development, preferably in an industrial environment
• Strong analytical skills and statistical analysis expertise
• Proficiency in technical writing and presenting technical data

Preferred Skills

• Experience in developing processes for oligonucleotides, peptides, and/or proteins
• Familiarity with GMP manufacturing processes
• Collaborative mindset with experience working in cross-functional teams