Scientist I/II, Functional Genomics

About the role

Seeking an experienced Senior Scientist to lead organoid model development for functional genomics and CRISPR screening, advancing biological discoveries through high-throughput approaches.

Responsibilities

• Develop, optimize, and scale organoid-based systems for genotype-phenotype analysis and high-throughput screening.
• Establish protocols for organoid culture, maintenance, and characterization ensuring reproducibility and robustness.
• Innovate experimental workflows and screening methodologies within organoid platforms.
• Collaborate with data science and AI/ML teams to analyze and interpret large-scale functional genomics data.
• Address technical challenges related to assay reproducibility, sample throughput, and quality control.
• Manage multiple projects independently, ensuring quality data delivery and alignment with team goals.
• Maintain detailed experimental records and contribute to scientific presentations.
• Mentor junior staff, fostering their technical and professional growth.
• Lead strategic planning and cross-functional collaborations to accelerate therapeutic discovery.

Qualifications & Skills

• Ph.D. in Molecular Biology, Genetics, Cell Biology, or related field with 0-4 years of research experience.
• Hands-on expertise in developing and maintaining organoid systems, including culture optimization and characterization.
• Experience with CRISPR-based genetic perturbations in 3D or organoid models.
• Familiarity with adapting organoid systems for high-throughput screening and automation.
• Strong troubleshooting, protocol adaptation, and methodology optimization skills.
• Excellent communication skills to present complex results to multidisciplinary teams.
• Ability to work collaboratively in fast-paced environments.

Preferred Skills

• Knowledge of perturb-seq, single-cell genomics, or spatial omics.
• Proficiency in data analysis using Python or R.
• Experience with CRISPR screening beyond organoid systems.