Scientist I Biopreservation

About the role

BioLife Solutions is a leading developer, manufacturer and supplier of class-defining cell and gene therapy bioproduction tools and services. Our solutions facilitate basic and applied research and commercialization of new therapies by maintaining the health of biologic source material and finished products during manufacturing, storage, and distribution.

Responsibilities

• Design and conduct experiments to evaluate Biopreservation strategies including cryopreservation, freezing, thawing and cold-chain storage workflows for mammalian cells and cellular therapeutics
• Develop and optimize biopreservation formulations and protocols for immune cells, stem cells, and other therapeutic cell types and tissues
• Perform characterization assays including viability, apoptosis, proliferation and phenotypic characterization
• Support development of end-to-end cell processing workflows involving cryopreserved starting materials and final drug products
• Evaluate the impact of process parameters (freezing rates, cryoprotectants, formulation buffers, thaw conditions, etc.) on product quality
• Auxiliary with scale-up and technology transfer considerations relevant to CGT manufacturing
• Perform and interpret assays including: Flow cytometry, Cell viability and apoptosis assays, Metabolic and functional assays, Post-thaw recovery kinetics
• Analyze experimental data and generate reports to guide protocol optimization
• Collaborate with cross-functional teams including scientific applications, product development and external clients and collaborators
• Contribute to technical reports, presentations, publications and white papers
• Participate in interactions with partners and customers evaluating biopreservation methods, including attending seminars and conferences

Requirements

• Deep understanding of the principles of cryopreservation, freeze-thaw processes and cold-chain
• Hands-on experience in and demonstrated ability to troubleshoot both adherent and in-suspension mammalian cell cultures
• Fluency and experience in designing and troubleshooting cell-based assays and analytical techniques including fluorescent imaging techniques, flow cytometry and ICS, ELISAs
• Strong skills in experiment design and DOE, data analysis and statistics, and scientific writing
• Training or research experience in Biopreservation methods, including cryobiology, vitrification methods, lyophilization and cellular stabilization
• Familiar with and demonstrated ability to apply GLP for lab work documentation
• Demonstrated ability to publish scientific work and skills for presentations at conferences
• Familiarity with process development concepts relevant to CGT manufacturing
• Demonstrated initiative to advance the field by generating innovative ideas and proposing solutions to key challenges in biopreservation and CGT/RMM
• Maintain scientific leadership by actively monitoring and studying emerging research and major developments in the field
• Scientific curiosity and strong problem-solving skills
• Strong communication and collaboration skills
• Attention to detail and careful documentation
• Passion for translating fundamental science into real-world therapeutic impact

Job Specifications

• BSc or MSc in Biology, Biomedical, Bioengineering or Chemical Engineering with 5-8 years of experience or a PhD with a minimum of 1-4 years of experience required
• Molecular Biology background and demonstrated competency in mol bio assays is a strong plus
• Occasional travel required

Benefits

• Medical, dental, vision, 401K with generous match
• Lifetime paid parental leave
• Life and disability insurance
• Time off programs of Vacation and Sick time
• Cash bonus or stock equity grants based on company performance

Equal Opportunity Employer

BioLife Solutions is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status, or disability status.