Scientist - Cellular Immunology Preclinical

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases.

About the Role

We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro, ex vivo, and in vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.

Responsibilities

• Conduct hands-on laboratory experiments following established protocols to maintain, expand, bank, and manage various cell lines and generate CAR T cells.
• Perform and validate cytotoxicity and flow cytometry assays.
• Perform and validate ELISpot, ELISA, Luminex, MSD, or other assays as needed.
• Perform lab-associated tasks in accordance with Cabaletta Bio lab safety policies and SOPs.
• Oversee in vivo mouse studies and perform related ex vivo assays as needed.
• Ensure proper maintenance and cleanliness of laboratory equipment and workspaces.
• Maintain accurate and well-organized records and electronic laboratory notebook.
• Analyze experimental data using basic statistical methods and software tools.
• Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions.
• Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0-2 years of experience, or Master's degree with a minimum of 5 years of experience, or Bachelor’s degree with a minimum of 10 years of experience.
• Hands-on experience with cell culture and basic molecular biology techniques.
• General lab skills, including aseptic techniques and human tissue handling.
• Prior experience and high proficiency in mammalian cell culture (aseptic techniques).
• Experience in primary cell husbandry, cytotoxicity assays, and flow cytometry.
• Prior involvement in animal studies or hands-on animal handling (advantageous).
• Highly organized and able to work independently.
• A high level of flexibility to support various activities and the ability to learn new techniques outside of existing expertise.
• Strong team orientation and passion for continuous self-development.
• Strong organizational skills, attention to detail, and the ability to follow protocols accurately.
• Effective written and verbal communication skills to share experimental findings and collaborate with team members.

Preferred Qualifications

• Extensive hands-on experience with primary immune cell cultures and assays.
• Experience working in a research or industry setting related to immunology and/or cell therapy.
• Experience in industry or in a startup industrial setting.
• Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.

Benefits

We offer competitive benefits, PTO, and stock option plans.