Scientist, Cardiac Vascular - In Vivo
About the role
Build Our Future Together At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team, serving as a key contributor to the design and execution of longitudinal in-vivo rodent studies supporting our cardiovascular disease programs. In this role, you will perform advanced surgical models of cardiac disease, conduct precision dosing and physiological monitoring, and generate high-quality functional and molecular data to support target validation and therapeutic development. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.
Responsibilities
- Perform surgical models of cardiac and vascular disease in mice and rats, including transverse aortic constriction (TAC), myocardial infarction (MI), and renal/kidney models (RKM)
- Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation with precision and consistency across longitudinal study timelines
- Implant and manage telemetry devices for continuous blood pressure and ECG monitoring in conscious, freely moving rodents
- Conduct invasive hemodynamic assessments using PV-loop methodology to quantify cardiac function
- Perform ex-vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion
- Manage end-to-end in-vivo study logistics, including animal health monitoring, surgical scheduling, and post-operative care
- Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software