Scientist Bioscience

Key Characteristics

The scientific focus is on nonmalignant, genetically defined, or ultrarare indications, where therapeutic goals, experimental design, and success criteria differ from oncology applications. Key characteristics include emphasis on precision, durability, and controlled activity rather than tumor eradication, engineering CART cells for long-term function, safety, and tight regulation, developing logic-gated or multi-input CAR systems to minimize off-target risk and enhance specificity, working with limited patient biology or scarce disease models, requiring thoughtful experimental design and data interpretation, supporting programs that may progress with smaller datasets but high mechanistic rigor, and experience or background exclusively in oncology is welcomed, but candidates must demonstrate the ability to adapt CART strategies to rare disease biological constraints and therapeutic objectives.

Key Responsibilities

• Execute predesigned experimental plans for CART cell engineering and validation
• Perform high-throughput lentiviral production and QC following established workflows, escalating issues as needed
• Conduct CAR validation and T-cell functional assays with guidance on experimental objectives
• Maintain accurate, traceable, and timely experimental documentation in electronic lab notebooks
• Communicate results clearly and proactively, including deviations, challenges, or unexpected findings
• Contribute to team troubleshooting discussions
• Work independently on assigned tasks while seeking input on experimental design changes
• Adhere strictly to Company data integrity, safety, and compliance standards

Required Qualifications

• Bachelor degree with relevant experience in Immunology, Cell Biology, Bioengineering, or related field
• Hand-on experience with CART cell therapy or engineered T cell platforms
• Demonstrated expertise in lentiviral vector production and associated QC assays
• Strong practical experience with primary T cell culture and manipulation
• Working knowledge of flow cytometry and functional T cell assays
• Ability to work independently while following established protocols