Scientist

About the role

We are seeking a Scientist to develop, optimize, and conduct microdissections of human blood vessels from tissue specimens as part of the Institutional Review Board (IRB)-approved or IRB exempt studies and overall laboratory research support for Laboratory of Malaria and Vector Research (LMVR). This is a full-time, on-site role in Rockville, MD.

Responsibilities

• Conduct microdissections of human vessels, prepare tissue for single-cell analysis of vascular cells, genetically manipulate human vessels, and assess function through molecular, imaging, and physiologic evaluations.
• Culture vascular cells, prepare cells for single-cell analysis, perform genetic manipulation of cultured cells, and assess function using molecular, imaging, and physiologic evaluations.
• Develop, refine, and perform microdissections of human blood vessels from tissue specimens for IRB-approved or exempt studies.
• Develop, refine, and conduct vascular cell culture and co-culture methods, and optimize approaches for studying human vessels and cultured cells at the single-cell level in IRB-approved or exempt studies.
• Characterize cultured cells using imaging, gene expression, and/or molecular sensors.
• Perform vascular phenotyping of rodent models, including mouse models of human diseases or conditions.
• Perform biochemical characterization of protein-protein interactions involved in vascular cell signaling.
• Work with staff on the interpretation of experiments performed by research scientists.
• Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis on the development of novel research treatments.
• Calibrate, maintain and troubleshoot instruments and equipment in the laboratory.
• Manage scientific equipment and resources, including reagents, frozen cell stocks, and animal samples, by overseeing acquisition, documentation, and storage.
• Write technical reports and prepare manuscripts.
• Oversee project data quality; analyze and interpret project data.
• Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.
• Develop and evaluate pharmacologic strategies that target protein-protein interactions to alter vascular function in human vessels, cells, or animal models of vascular physiology or disease.
• Prepare oral presentations and posters for internal and external groups/conferences.
• Co-author manuscripts on research projects; publish in peer-reviewed journals.
• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.
• Produce research reports and regularly communicate results to staff and collaborators.
• Train staff on proper equipment use and a broad range of laboratory techniques.

Requirements

• Master’s degree in Biochemical Sciences or related field.
• A minimum of SIX (6) years of laboratory research experience.
• Experience with cell culture and vascular biology research techniques.
• Proficiency with Microsoft Office Suite (PowerPoint, Outlook, Excel, Word).
• Knowledge of Good Clinical Practice (GCP).
• Ability to analyze and interpret complex scientific data and produce technical reports.
• Strong written and verbal communication skills, including scientific publishing and presentations.
• Ability to work independently and collaboratively in a research laboratory environment.
• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse.

Qualifications

Candidates with an active public trust or suitability are preferred.

Skills

• Experience with single-cell analysis techniques.
• Experience working with rodent models of disease.
• Background in genetic manipulation and molecular biology techniques.
• Experience presenting at national scientific meetings or publishing in peer-reviewed journals.
• Prior experience mentoring or training laboratory staff.

Pay

The annual salary range for this position is $130,000.00-$216,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

Benefits

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)