Scientist 3, Functional Immunogenomics

The Position

The Department of Cell and Tissue Genomics (CTG) at Genentech is seeking a highly motivated and innovative Scientist 3 to leverage cutting-edge genomics strategies for target discovery and next-generation therapeutic engineering.

The Department

The Department of Cell and Tissue Genomics (CTG) is part of Genentech, a leading biotechnology company focused on developing innovative therapies for patients with serious diseases.

Responsibilities

• Develop and deploy molecular engineering technologies, biologically relevant models, and state-of-the-art genomics, functional, and imaging read-outs to interrogate complex immunological disease mechanisms at scale.
• Integrate complex experimental systems with deep biological insights to directly drive the identification of novel molecular mechanisms, target candidates, and cell therapy strategies for immune-mediated diseases.
• Work collaboratively with scientists of diverse expertise, including immunology, cell therapy, genomics, human genetics, computational biology, and AI/ML.
• Thrive at the interface of technology development and disease biology, building and applying cutting-edge molecular tools to extract actionable biological insights.

Requirements

• Doctorate degree in a relevant field, including molecular biology, genetics, immunology, systems biology, synthetic biology, developmental biology, biochemistry, and/or biomedical engineering.
• Deep expertise in immunology, including primary immune cell culture and functional assays. In vivo experience a plus.
• Strong foundational background in molecular biology and functional genomics tools, such as CRISPR (CRISPRko, CRISPRi/a, base editing), deep mutational scanning, lineage tracing, molecular recorders. Experience deploying these at scale and in primary immune cells and/or iPSCs is a plus.
• Experience in high-content genomics, including NGS, single-cell genomics, proteomics and/or imaging.
• Ability to manage multiple projects in parallel, collaborate effectively with multidisciplinary teams, and lead research projects.
• Sustained record of productivity in the form of publications and/or patents.
• Proficiency in a broad range of biochemical, molecular, and cell biology techniques including flow cytometry.
• Excellent problem-solving skills and the ability to independently design, execute, and interpret experiments.
• Strong communication skills and a genuine enthusiasm for collaborative, team-based science.
• Motivation to learn new experimental approaches and computational analyses, and the curiosity to explore unconventional ideas.

Preferred

• Data Analysis: Experience in the analysis of single cell and genomic data using R and/or Python.

Qualifications

• No prior industry experience required, but an open and curious scientific mind is essential, as well as strong communication skills.

Skills

• Open and curious scientific mind.
• Strong communication skills.
• Motivation to learn new experimental approaches and computational analyses.
• The ability to thrive at the intersection of technology development and disease biology.

Benefits

Genentech offers a comprehensive benefits package that includes relocation benefits, a competitive salary range ($103,400 - $192,000), discretionary annual bonuses, and a wide array of benefits detailed at the provided link.

Genentech is an equal opportunity employer and is committed to fostering a diverse and inclusive workplace. We prohibit unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.