Scientist 1, Chemistry Development - Entry Level

About the role

Works within a team to provide synthetic oligonucleotides through the use of automated oligonucleotide synthesizers and Liquid Chromatography systems which support the development of automated assays using nucleic acid isolation and real-time amplification/detection technology within the Molecular Diagnostic plants.

Responsibilities

• Follows established protocols for the synthesis and purification of oligonucleotides used in manufacturing and R&D.
• Follows established protocols for the preparation of buffers used in the oligonucleotide and conjugation processes.
• Follows established protocols for protein conjugation procedures.
• Contributes to the completion of goals associated with specific oligonucleotide process optimization projects.
• Contributes to developing solutions and providing recommendations as to the appropriate course of action to technical problems associated with the preparation of synthetic oligonucleotides.
• Provides documentation and validation support in execution of synthesis and/or purification process changes.
• Performs laboratory work and documentation in accordance with GMP, GLP and company guidelines.
• Perform tasks under general supervision.

Qualifications

• Basic understanding in the use of the liquid chromatography manual or automated systems.
• Basic understanding of chromatography theory and hands-on experience with HPLC (High Performance Liquid Chromatography).
• Excellent verbal and written communication skills are necessary together with the ability to interact effectively in team and cross-functional environments.
• Understanding of the GMP and GLP laboratory guidelines.
• Optional experience includes the use of a DNA (oligonucleotide) and/or Peptide synthesizer and having an understanding of the oligonucleotide synthesis chemistry.
• Understanding of Lean manufacturing tools highly beneficial.

Education and experience

• Minimum of a Bachelor's Degree in Biochemistry, Chemistry, Molecular Biology or related discipline.
• Prefer a minimum of 1 year of industrial or academic experience in the synthesis and/or purification of oligonucleotides.

Pay and schedule

• Rate: $20-30/hr
• 1st Shift, M - F 8:30am – 5pm
• 40 hours/week