Scientific Director, Lead Generation Biology

About the role

Responsible for lead generation biology platforms that support Neurocrine’s early research portfolio. Oversees key capabilities including broad assay development, routine cellular and biochemical pharmacology assays for SAR, SPR and other biophysical and binding approaches, and fit-for-purpose screening workflows across broad therapeutic areas, target classes and drug modalities. Leads a laboratory organization focused on delivering robust, high-quality pharmacology data through scalable, reproducible, and well-characterized experimental workflows. Partners closely with therapeutic areas, protein engineering, chemistry, and other cross-functional R&D teams to align assay strategy, execution, and data generation with the needs of discovery programs.

Responsibilities

• Leads discovery biology platform capabilities that support Neurocrine’s early research portfolio, including assay development, routine cellular and biochemical SAR assays, SPR and other biophysical approaches, and fit-for-purpose screening workflows
• Develops, optimizes, validates, and implements robust assay systems to generate high-quality, reproducible pharmacology data across multiple target classes and therapeutic modalities
• Maintains deep knowledge of state-of-the-art discovery biology, assay development, pharmacology screening, SAR-supporting assay cascades, biophysical methods, and platform technologies relevant to early drug discovery
• Translates discovery program needs into practical assay strategies, scalable workflows, and executable tactical plans
• Leads and manages a laboratory organization responsible for timely execution of discovery assays, data quality, platform performance, and continuous improvement of experimental capabilities
• Evaluates, implements, and advances new technologies, assay formats, instrumentation, and workflow improvements that enhance the quality, efficiency, scalability, and impact of discovery biology platforms
• Mentors, develops, and trains scientists and technical staff with expertise in assay development, cellular and biochemical pharmacology, biophysics, screening technologies, data interpretation, and related discovery biology disciplines
• Contributes scientific expertise to cross-functional project teams by providing guidance on assay feasibility, pharmacology data generation, screening cascade design, and interpretation of discovery biology results
• Represents discovery biology platforms in internal forums, project team discussions, external scientific meetings, and other venues as appropriate
• Establishes and manages external collaborations with contract research organizations, technology providers, and academic or industry partners to supplement internal capabilities and support discovery program objectives
• Possesses an in-depth understanding of the competitive drug development environment

Requirements

• Bachelor's degree in biological sciences preferably related to behavioral neuroscience, pharmacology or biopsychology and 12+ years of pharmaceutical/biotech experience; with a strong research background in neuroscience, molecular and cellular biology, and/or biochemistry OR
• Master's degree in biological sciences preferably related to behavioral neuroscience, pharmacology or biopsychology and 10+ years of related experience OR
• PharmD or PhD and 8+ years of related experience
• Maintains deep knowledge of state-of-the-art discovery biology, assay development, pharmacology screening, SAR-supporting assay cascades, biophysical methods, and platform technologies relevant to early drug discovery
• Applies scientific and technical expertise to guide the development, optimization, validation, and execution of robust cellular, biochemical, and biophysical assays across multiple target classes and therapeutic modalities
• Requires in-depth knowledge of discovery biology operations, assay strategy, data quality expectations, laboratory workflows, business priorities, and the company’s research goals
• Demonstrated ability to translate discovery program needs into practical assay strategies, scalable workflows, and executable tactical plans
• Strong leadership, mentoring, and people-development skills, with experience supervising scientists and technical staff and/or leading matrixed project or platform teams
• Excellent communication, problem-solving, analytical thinking, collaboration, and influencing skills
• Ability to lead multiple platform areas and work closely with therapeutic area biology, chemistry, translational science, DMPK, automation, informatics, and other cross-functional partners
• Strong understanding of the drug discovery process and the role of fit-for-purpose pharmacology assays in supporting early research decision-making
• Scientific expertise and technical know-how across a broad range of relevant techniques, such as cell culture, cellular pharmacology, biochemical assays, molecular biology, receptor pharmacology, enzymology, protein-based assays, imaging-based assays, and biophysical approaches including SPR
• Experience developing, implementing, troubleshooting, and scaling assays for routine execution in support of discovery programs
• Critical thinking, scientific curiosity, and passion for enabling high-quality drug discovery through robust experimental platforms
• Track record of solving challenging technical and operational problems independently and creatively, with evidence of scientific impact through internal contributions, platform advancement, external presentations, publications, or related accomplishments
• Experience evaluating and implementing new technologies, assay formats, instrumentation, automation, or data-analysis workflows to improve discovery biology capabilities is preferred

Qualifications

• Deep knowledge of state-of-the-art discovery biology, assay development, pharmacology screening, SAR-supporting assay cascades, biophysical methods, and platform technologies relevant to early drug discovery
• Strong leadership, mentoring, and people-development skills, with experience supervising scientists and technical staff and/or leading matrixed project or platform teams
• Excellent communication, problem-solving, analytical thinking, collaboration, and influencing skills
• Strong understanding of the drug discovery process and the role of fit-for-purpose pharmacology assays in supporting early research decision-making
• Scientific expertise and technical know-how across a broad range of relevant techniques, such as cell culture, cellular pharmacology, biochemical assays, molecular biology, receptor pharmacology, enzymology, protein-based assays, imaging-based assays, and biophysical approaches including SPR
• Experience developing, implementing, troubleshooting, and scaling assays for routine execution in support of discovery programs
• Critical thinking, scientific curiosity, and passion for enabling high-quality drug discovery through robust experimental platforms
• Track record of solving challenging technical and operational problems independently and creatively, with evidence of scientific impact through internal contributions, platform advancement, external presentations, publications, or related accomplishments
• Experience evaluating and implementing new technologies, assay formats, instrumentation, automation, or data-analysis workflows to improve discovery biology capabilities is preferred

Skills

• Deep knowledge of state-of-the-art discovery biology, assay development, pharmacology screening, SAR-supporting assay cascades, biophysical methods, and platform technologies relevant to early drug discovery
• Strong leadership, mentoring, and people-development skills, with experience supervising scientists and technical staff and/or leading matrixed project or platform teams
• Excellent communication, problem-solving, analytical thinking, collaboration, and influencing skills
• Strong understanding of the drug discovery process and the role of fit-for-purpose pharmacology assays in supporting early research decision-making
• Scientific expertise and technical know-how across a broad range of relevant techniques, such as cell culture, cellular pharmacology, biochemical assays, molecular biology, receptor pharmacology, enzymology, protein-based assays, imaging-based assays, and biophysical approaches including SPR
• Experience developing, implementing, troubleshooting, and scaling assays for routine execution in support of discovery programs
• Critical thinking, scientific curiosity, and passion for enabling high-quality drug discovery through robust experimental platforms
• Track record of solving challenging technical and operational problems independently and creatively, with evidence of scientific impact through internal contributions, platform advancement, external presentations, publications, or related accomplishments
• Experience evaluating and implementing new technologies, assay formats, instrumentation, automation, or data-analysis workflows to improve discovery biology capabilities is preferred

Benefits

• Annual base salary range: $188,700.00 - $257,000.00
• Target annual bonus: 35% of earned base salary
• Eligibility for equity-based long-term incentive program
• Retirement savings plan with company match
• Paid vacation, holiday, and personal days
• Paid caregiver/parental and medical leave
• Health benefits including medical, prescription drug, dental, and vision coverage

Pay

$188,700.00 - $257,000.00 annually

Schedule

Full-time