Research Technician I- Lefkowitz Lab

About the role

This position will involve working closely with a highly experienced Assistant Professor in the lab to develop small molecule modulators of GPCRs and signaling proteins, and to investigate the structural basis underlying mechanisms of drug action and effector interactions using pharmacological and structural biology approaches, including cryo-electron microscopy, with responsibilities including protein purification, preparation of samples for cryo-EM studies, and structural data analysis. The ideal candidate will contribute to data analysis and interpretation and communicate findings clearly. This role requires a willingness to take initiative, engage deeply with science, maintain accurate documentation, and stay informed through relevant scientific literature.

Responsibilities

• Operate and calibrate complex scientific instrumentation.
• Aid with laboratory equipment maintenance.
• Order, organize, and curate lab supplies and inventory.
• Actively contribute to laboratory meetings and planning sessions.
• Record keeping and other organizational duties.

Requirements

• Bachelor’s/master’s degree in biology, Chemistry or a related field.
• Prior experience working in a research laboratory.
• Experience in protein biochemistry including expression, chromatographic purification, and analysis is a strong plus.
• Understanding basic molecular biology, biochemistry, and related fields.
• Excellent analytical, communication, problem solving, and organizational skills.
• Able to work both independently and as a team member while engaged in collaborative studies.
• Able to learn complex tasks with instruction, and to use experience to perform a variety of new techniques.
• Actively seeks opportunities to increase skills and expertise.

Qualifications

• Available to join the lab immediately, with a preference for individuals able to make a sustained commitment.
• The position is also well suited for enthusiastic senior undergraduate students, as well as post-bac or gap-year trainees, particularly those planning to pursue MD, PhD, or MD/PhD training, as past trainees from this position have gone on to leading universities nationwide.
• Applicants from local universities such as Duke and neighboring institutions with strong motivation and preparation are encouraged to apply.

Skills

• Strong analytical and communication skills.
• Ability to work independently and as part of a team.
• Knowledge of molecular biology, biochemistry, and related fields.
• Experience with protein biochemistry, including expression, purification, and analysis.
• Basic understanding of cryo-electron microscopy and structural biology.

Benefits

• Opportunity to work in a diverse and encouraging research environment.
• Opportunity to contribute to groundbreaking research.
• Weekly group meetings with the Investigator and lab members in a collaborative and highly team-oriented setting.

Pay

Compensation Range: $16.73 (minimum) - $20.94 (midpoint) - $27.21 (maximum)

Schedule

This will be a 1-year fixed term position.