Research Senior Scientist

Cambridge, MA

About the role

Takeda Development Center Americas, Inc. is seeking a Research Senior Scientist to serve as the DMPK representative on projects supporting gastroenterology, autoimmune, and oncology Drug Discovery Units (DDUs) for developing novel drug therapies. This role involves providing molecular and cellular analysis support, advancing early drug development and translational research, and collaborating with internal stakeholders and external resources.

Responsibilities

• Support early drug development and translational research by providing scientific support with a focus on cellular and molecular quantification using cutting-edge technology, such as flow cytometry, ddPCR, Nanostring nCounter, and other assay platforms.
• Communicate with internal stakeholders regarding project needs, progress updates, and DMPK deliverables.
• Perform innovative assay development, troubleshoot bioanalytical assay-related issues, and actively identify, adopt, or develop novel technologies to meet project needs alongside key stakeholders in DMPK, DDUs, and other Quantitative Preclinical and Translational Sciences (QPTS) groups.
• Design, validate, and implement new methodologies and processes (including in silico approaches) that contribute to the research goals of the group/department.
• Summarize and present experimental results in cross-functional project teams and DMPK meetings.
• Provide scientific monitoring and guidance to external resources (CROs) for method transfer, development, troubleshooting, qualification, validation, and reporting to support non-clinical and pre-clinical development programs.
• Ensure the appropriate conduct of studies, lead the interpretation of study results, and prepare study reports suitable for internal or regulatory use.

Requirements

• Doctorate degree in Pathobiology or a related field.
• Prior experience must include leading hypothesis-driven investigative research, including in vitro, ex vivo, and in vivo studies to drive novel therapeutic development, such as animal handling and biological sample handling.
• Design, optimize, and implement molecular, cellular, bioanalytical, and biomarker assays, including ELISA, PCR, neutralization assays, proliferation, flow cytometry, and ELISPOT to assess transgenes, recombinant proteins, cytokines, antibodies, and immunogenicity for efficacy studies.
• Apply advanced computational and statistical approaches to analyze and interpret large, complex datasets to support decision-making.
• Analyze nucleotide and peptide sequences using bioinformatics or in silico tools to create and evaluate synthetic primers, plasmids, and other synthetic genes and peptides to support therapeutics development.

Benefits

• Medical, dental, and vision insurance.
• 401(k) plan with company match.
• Short-term and long-term disability coverage.
• Basic life insurance.
• Tuition reimbursement program.
• Paid volunteer time off.
• Company holidays.
• Well-being benefits.
• Up to 80 hours of sick time per calendar year.
• New hires eligible to accrue up to 120 hours of paid vacation.
• Eligibility for short-term and/or long-term incentives for U.S.-based employees.

Pay

$137,000 - $215,270 per year.

Schedule

Full time.